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The biosynthesis of structural proteins in parasites

Funding: 2006: $80,000
2007: $70,000
2008: $70,000

Project Member(s): Wallach, M.

Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)

Start year: 2006

Summary: Transmission from host to host is fundamental to any parasite's lifecycle. For many, this means a free-living phase in the outside world, during which they protect themselves from harsh environmental conditions; nematode larvae, for example, are protected by their cuticle and coccidians produce oocyst walls. These barriers are created when large proteins are processed into smaller tyrosine-rich fragments which then crosslink to form a protective structure. We will discover the processing pathways involved in the formation of oocyst walls of coccidia. This knowledge will lead to a better understanding of structural protein biosynthesis in parasites and the discovery of new control targets.

Publications:

Mai, K, Sharman, PA, Walker, RA, Katrib, M, De Souza, D, McConville, M, Wallach, M, Belli, SI, Ferguson, DJ & Smith, NC 2009, 'Oocyst wall formation and composition in coccidian parasites', Memorias do Instituto Oswaldo Cruz, vol. 104, no. 2, pp. 281-289.
View/Download from: UTS OPUS

Keywords: protozoan parasites, proteases, dityrosine crosslinking, walls and cuticles, protein oxidation, oocysts,

FOR Codes: Parasitology, Medical Parasitology, Infectious Diseases, Treatments (e.g. chemicals antibiotics), Treatments (e.g. chemicals, antibiotics), Veterinary Pharmaceutical Treatments (e.g. Antibiotics), Human Pharmaceutical Treatments (e.g. Antibiotics), Veterinary Parasitology