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Microbial and Cellular Imaging and Analysis Facility

Funding: 2009: $750,000

Project Member(s): Whitchurch, C., Harry, E., Phillips, M., Ford, M., Ralph, P., Doblin, M., Smith, N.

Funding or Partner Organisation: Australian Research Council (ARC Linkage Infrastructure)

Start year: 2009

Summary: This facility will provide sophisticated state-of-the-art technologies for high resolution imaging and analysis of microorganisms and their interactions with each other, host cells and the environment. These technologies will also be available for high resolution studies of other biological, environmental and disease processes. Importantly this facility will be housed within PC2 and QAP laboratories providing rare access to these advanced technologies for researchers with these containment requirements such as those studying pathogens (viruses, bacteria, parasites, fungi), GMOs, and exotic species. This facility will also develop and implement cutting-edge technologies for high resolution biological imaging and analysis.

Publications:

Redpath, GM, Sophocleous, RA, Turnbull, L, Whitchurch, CB & Cooper, ST 2016, 'Ferlins show tissue-specific expression and segregate as plasma membrane/late endosomal or trans-Golgi/recycling ferlins.', Traffic, vol. 17, no. 3, pp. 245-266.
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Chaiyadet, S, Sotillo, J, Smout, M, Cantacessi, C, Jones, MK, Johnson, MS, Turnbull, L, Whitchurch, CB, Potriquet, J, Laohaviroj, M, Mulvenna, J, Brindley, PJ, Bethony, JM, Laha, T, Sripa, B & Loukas, A 2015, 'Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype', JOURNAL OF INFECTIOUS DISEASES, vol. 212, no. 10, pp. 1636-1645.
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Smout, MJ, Sotillo, J, Laha, T, Papatpremsiri, A, Rinaldi, G, Pimenta, RN, Chan, LY, Johnson, MS, Turnbull, L, Whitchurch, CB, Giacomin, PR, Moran, CS, Golledge, J, Sripa, B, Mulvenna, JP, Brindley, PJ & Loukas, A 2015, 'Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia', PLoS Pathogens, vol. 11, no. 10.
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Keywords: Wide field Fluorescence Microscopy, Electron Microscopy, Infectious Diseases, Cell biology, Ultrastructural analysis, Macromolecular assemblies,

FOR Codes: Diabetes, Infectious Diseases, Infectious Agents, Biochemistry and Cell Biology not elsewhere classified, Other, Endocrine organs and diseases (incl. diabetes)