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Devices that use Ion Channels

Funding: 2009: $85,000
2010: $85,000
2011: $85,000

Project Member(s): Valenzuela, S.

Funding or Partner Organisation: Australian Research Council (ARC Linkage Projects)
Seagull Technology Pty Ltd
Surgical Diagnostics Pty Limited (Surgical Diagnostics Pty Ltd)

Start year: 2009

Summary: This project aims to develop novel biomimetic sensor devices that will have wide applicability allowing researchers to study ion channel proteins, membrane transport processes and as a drug screening tool. The project will also develop a simple biomimetic probe for Electromagnetic Radiation Compatibility (EMC). This project is in a unique position of having a project team which combines expertise in classical ion channel studies, along with real freedom-to-operate by holding the recently licensed primary world-wide patent in tethered lipid membranes and the primary world-wide patent in therapeutic drug delivery using electroconductive polymers coupled to ultrasound.'',

Publications:

Valenzuela, S, Alkhamici, H, Brown, LJ, Almond, OC, Goodchild, SC, Carne, S, Curmi, PM, Holt, S & Cornell, BA 2013, 'Regulation Of The Membrane Insertion And Conductance Activity Of The Metamorphic Chloride Intracellular Channel Protein CLIC1 By Cholesterol', Plos One, vol. 8, no. 2, pp. 1-8.
View/Download from: UTS OPUS or Publisher's site

Keywords: nanobiotechnology, lipid bilayer membrane, ion channel, biosensor, drug discovery,

FOR Codes: Medical Instruments, Biomedical Engineering, Biochemistry and Cell Biology, Diagnostic Methods, Nanotechnology