Devices that use Ion Channels

Funding: 2009: $85,000
2010: $85,000
2011: $85,000

Project Member(s): Valenzuela, S.

Funding or Partner Organisation: Australian Research Council (ARC Linkage Projects)
Seagull Technology Pty Ltd
Surgical Diagnostics Pty Limited (Surgical Diagnostics Pty Ltd)

Start year: 2009

Summary: This project aims to develop novel biomimetic sensor devices that will have wide applicability allowing researchers to study ion channel proteins, membrane transport processes and as a drug screening tool. The project will also develop a simple biomimetic probe for Electromagnetic Radiation Compatibility (EMC). This project is in a unique position of having a project team which combines expertise in classical ion channel studies, along with real freedom-to-operate by holding the recently licensed primary world-wide patent in tethered lipid membranes and the primary world-wide patent in therapeutic drug delivery using electroconductive polymers coupled to ultrasound.'',

Publications:

Valenzuela, SM, Alkhamici, H, Brown, LJ, Almond, OC, Goodchild, SC, Carne, S, Curmi, PMG, Holt, SA & Cornell, BA 2013, 'Regulation of the Membrane Insertion and Conductance Activity of the Metamorphic Chloride Intracellular Channel Protein CLIC1 by Cholesterol', PLOS ONE, vol. 8, no. 2, pp. 1-8.
View/Download from: Publisher's site

Keywords: nanobiotechnology, lipid bilayer membrane, ion channel, biosensor, drug discovery,

FOR Codes: Medical Instruments, Biomedical Engineering, Biochemistry and Cell Biology, Diagnostic Methods, Nanotechnology, Provision of health and support services not elsewhere classified, Diagnosis of human diseases and conditions

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.