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Single cell imaging of trace elements by laser ablation - inductively coupled plasma - mass spectrometry

Funding: 2010: $135,000
2011: $118,000
2012: $90,000

Project Member(s): Doble, P.

Funding or Partner Organisation: Mental Health Research Institute of Victoria
Australian Research Council (ARC Linkage Projects)
Agility Management Pty Ltd (Agilent Technologies Australia)
Kenelec Scientific

Start year: 2011

Summary: The precise mechanism of how many diseases function on the cellular level is not well understood. Trace elements are important to normal cellular function and have the potential to cause significant damage if delicate levels are disturbed. This project will introduce a new, cost-effective alternative to the synchrotron for mapping of trace elements in single cells. This breakthrough science will transform a common analytical instrument into a powerful new tool for probing the cellular mechanisms of chronic illness. This frontier technology will help determine the role of trace metals in the development of neurodegenerative disease

Publications:

Austin, CE, Smith, TM, Bradman, A, Hinde, K, Joannes-Boyau, R, Bishop, DP, Hare, DJ, Doble, PA, Eskenazi, B & Arora, M 2013, 'Barium distributions in teeth reveal early-life dietary transitions in primates', Nature, vol. 498, pp. 216-219.
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Hare, DJ, Lear, J, Bishop, DP, Beavis, AB & Doble, PA 2013, 'Protocol for production of matrix-matched brain tissue standards for imaging by laser ablation-inductively coupled plasma-mass spectrometry', Analytical Methods, vol. 5, no. 8, pp. 1915-1921.
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FOR Codes: Application Software Packages (excl. Computer Games), Biochemistry and Cell Biology, Expanding Knowledge in the Biological Sciences, Neurodegenerative Disorders Related to Ageing, Analytical Spectrometry