Prevention of beta cell destruction in type 1 diabetes by immunotherapy using parasite-derived molecules

Project Member(s): O'Brien, B., Donnelly, S., Simpson, A.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC Project Grants)

Start year: 2011

Publications:

Lund, ME, O'Brien, BA, Hutchinson, AT, Robinson, MW, Simpson, AM, Dalton, JP & Donnelly, S 2014, 'Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse', PLOS ONE, vol. 9, no. 1, p. e86289.
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Robinson, MW, Dalton, JP, O'Brien, BA & Donnelly, S 2013, 'Fasciola hepatica: The therapeutic potential of a worm secretome', INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 43, no. 3-4, pp. 283-291.
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Robinson, MW, Alvarado, R, To, J, Hutchinson, AT, Dowdell, SN, Lund, M, Turnbull, L, Whitchurch, CB, O'Brien, BA, Dalton, JP & Donnelly, S 2012, 'A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase', FASEB JOURNAL, vol. 26, no. 11, pp. 4614-4627.
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FOR Codes: Autoimmunity, Diabetes, Innate Immunity, Autoimmunity , Clinical health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.