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Identifying how bacterial cells find their middle: a new perspective

Funding: 2012: $117,000
2013: $105,000
2014: $105,000

Project Member(s): Harry, E.

Funding or Partner Organisation: Nara Institute of Science and Technology
Australian Research Council (ARC Discovery Projects)
Australian Research Council (Other funds for ARC projects)

Start year: 2012

Summary: Spatial regulation of cell division is vital to ensure equal partitioning of DNA into newborn cells. Positioning of the division site in bacteria is an area of research considered to be 'done and dusted'. However, our recent discoveries have led to an entirely different model for division site placement in bacteria that proposes direct roles for DNA replication and chromosome organization. This project combines newly developed technology, with complementary expertise in bacterial cell division and DNA replication, to test this model and facilitate our understanding of this fundamental process crucial to bacterial growth and infection.

Publications:

Hajduk, IV, Rodrigues, CD & Harry, EJ 2016, 'Connecting the dots of the bacterial cell cycle: Coordinating chromosome replication and segregation with cell division.', Seminars in cell & developmental biology, vol. 53, pp. 2-9.
View/Download from: UTS OPUS or Publisher's site

Keywords: cell divisionbacteriaDNA replication

FOR Codes: Bacteriology, Expanding Knowledge in the Biological Sciences, Microbial Genetics, Expanding Knowledge in Technology