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Low temperature storage facility for production of insulin-secreting liver cells

Project Member(s): Simpson, A.

Funding or Partner Organisation: The Rebecca L Cooper Medical Research Foundation L (Rebecca L Cooper Medical Research Foundation Proje)

Start year: 2012

Summary: The specific aims of this project (2011-12) were to determine if using a lentiviral vector (HMD) to deliver the furin-cleavable human insulin (INS-FUR) gene directly into the livers of FRG humanised mice results in the permanent reversal of diabetes and pancreatic transdifferentiation of the human liver cells and to characterise the expression profiles of genes and proteins in human liver cells that are permissive to in vivo lentiviral transduction and subsequent transdifferentiation into insulin-secreting cells

FOR Codes: Health, Clinical Sciences