Chip liquid chromatography-inductively coupled plasma-mass spectrometry: A new hyphenated microfluidic instrument for metallomics - LP120200079

Funding: 2012: $35,000
2013: $70,000
2014: $70,000
2015: $35,000

Project Member(s): Doble, P., Fryer, F.

Funding or Partner Organisation: University of Tasmania
Australian Research Council (ARC Linkage Projects)
Agilent Technologies (Agilent Technologies Australia Pty Ltd)

Start year: 2013

Summary: This project will develop the next generation of hyphenated microfluidic chip liquid chromatography-inductively coupled plasma-mass spectrometer (chipLC-ICP-MS) for metallomics. We will develop an interface to efficiently couple a chipLC system with an ICP-MS. A pneumatically-assisted nebuliser will be integrated within the ChipLC. This configuration will be superior to current nano-LC-ICP-MS instruments, notably by eliminating complicated, tedious capillary connectors. Incorporating 2 columns in chip configurations will enable multidimensional liquid chromatography separations. Outcomes will include a robust, highly sensitive and easy-to-use instrument for biological applications and Australian leadership in metallomic research.

Publications:

Ueland, M, Blanes, L, Taudte, RV, Stuart, BH, Cole, N, Willis, P, Roux, C & Doble, P 2016, 'Capillary-driven microfluidic paper-based analytical devices for lab on a chip screening of explosive residues in soil', Journal of Chromatography A, vol. 1436, pp. 28-33.
View/Download from: Publisher's site

Keywords: metallomics,microfluidic systems,Lab-on-a-chip

FOR Codes: Analytical Spectrometry, Scientific Instruments

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.