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The atlas of trace metals in the mouse brain: A new tool for neuroscientists - LP120200081

Funding: 2012: $42,500
2013: $87,000
2014: $87,000
2015: $42,500

Project Member(s): Doble, P.

Funding or Partner Organisation: Electro Scientific Industries Europe Ltd
Australian Research Council (ARC Linkage Projects)
Agilent Technologies (Agilent Technologies Australia Pty Ltd)
University of Melbourne (The University of Melbourne)

Start year: 2013

Summary: Brain atlases are integral to neuroscience research, depicting structural and functional information. We will produce the first interactive atlas of metals within the mouse brain, for neuroscientists studying the link between trace metals and neurodegenerative diseases. There is currently no viable method to produce elemental atlases. An interdisciplinary team, including chemists, neuroscientists and two world-leading analytical industry partners will improve imaging techniques to reduce the time needed to image brains; examine the effect of trace metal redistribution; produce 3D models of trace metal distribution in the brain; construct a 'standard model'; and develop an invaluable online resource to make the atlas accessible worldwide.

Publications:

Billings, JL, Gordon, SL, Rawling, T, Doble, PA, Bush, AI, Adlard, PA, Finkelstein, DI & Hare, DJ 2019, 'l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.', Journal of neurochemistry, vol. 150, no. 1, pp. 88-106.
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Bishop, DP, Clases, D, Fryer, F, Williams, E, Wilkins, S, Hare, DJ, Cole, N, Karst, U & Doble, PA 2016, 'Elemental bio-imaging using laser ablation-triple quadrupole-ICP-MS', JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, vol. 31, no. 1, pp. 197-202.
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Hare, DJ, Raven, EP, Roberts, BR, Bogeski, M, Portbury, SD, McLean, CA, Masters, CL, Connor, JR, Bush, AI, Crouch, PJ & Doble, PA 2016, 'Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex', NEUROIMAGE, vol. 137, pp. 124-131.
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Hare, DJ, New, EJ, de Jonge, MD & McColl, G 2015, 'Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution.', Chemical Society reviews, vol. 44, pp. 5941-5958.
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Adlard, PA, Sedjahtera, A, Gunawan, L, Bray, L, Hare, DJ, Lear, J, Doble, PA, Bush, A, Finkelstein, D & Cherny, R 2014, 'A novel approach to rapidly prevent age-related cognitive decline', Aging Cell, vol. 13, no. 2, pp. 351-359.
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Hare, DJ, George, J, Bray, L, Volitakis, I, Vais, A, Ryan, T, Cherny, R, Bush, A, Masters, C, Adlard, P, Doble, PA & Finkelstein, D 2014, 'The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue', Journal of Analytical Atomic Spectrometry, vol. 29, pp. 565-570.
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Keywords: brain atlas,laser ablation,inductively coupled plasma-mass spectrometry,trace elements

FOR Codes: Analytical Biochemistry, Neurodegenerative Disorders Related to Ageing, Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified