A Research Platform for Exploring the Genotype:Phenotype Nexus

Project Member(s): Harry, E., Djordjevic, S., Hutvagner, G., Whitchurch, C.

Funding or Partner Organisation: Macquarie University
University of New South Wales (The University of New South Wales Partnership Fund)
University of Newcastle (The University of Newcastle)
University of Sydney (The University of Sydney Partnership Fund)
Australian Research Council (ARC Linkage Infrastructure)

Start year: 2013

Summary: The translation of the genetic code of an organism to produce all its characteristic traits, collectively known as the phenome, is crucial for understanding how biological systems work. However, while high-throughput (next generation) DNA sequencing has led to exponential growth in genomic data, about one third of the genes sequenced have still not been assigned a function. This proposal aims to reduce this bottleneck of information flow with the purchase of a suite of newly-available, automated, high throughput technologies that will provide a combination of fast, cutting-edge approaches to accelerate research at the genome-phenome nexus, and allow an integrated view of the living cell.

Publications:

O'Rourke, MB, Djordjevic, SP & Padula, MP 2018, 'The quest for improved reproducibility in MALDI mass spectrometry', Mass Spectrometry Reviews, vol. 37, no. 2, pp. 217-228.
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Wyrsch, ER, Roy Chowdhury, P, Chapman, TA, Charles, IG, Hammond, JM & Djordjevic, SP 2016, 'Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis', Frontiers in Microbiology, vol. 7, no. JUN.
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Keywords: genomics,phenomics,systems biology

FOR Codes: Biochemistry and Cell Biology not elsewhere classified, Infectious Diseases, Systems Biology, Expanding Knowledge in the Biological Sciences, Bioinformatics, Cancer and Related Disorders, Biochemistry and cell biology not elsewhere classified , Bioinformatics and computational biology, EXPANDING KNOWLEDGE, Clinical health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.