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A Research Platform for Exploring the Genotype:Phenotype Nexus

Funding: 2013: $650,000

Project Member(s): Harry, E., Djordjevic, S., Hutvagner, G., Whitchurch, C.

Funding or Partner Organisation: Macquarie University
Australian Research Council (ARC Linkage Infrastructure)
University of New South Wales (The University of New South Wales Partnership Fund)
University of Newcastle (The University of Newcastle)
University of Sydney (The University of Sydney Partnership Fund)

Start year: 2013

Summary: The translation of the genetic code of an organism to produce all its characteristic traits, collectively known as the phenome, is crucial for understanding how biological systems work. However, while high-throughput (next generation) DNA sequencing has led to exponential growth in genomic data, about one third of the genes sequenced have still not been assigned a function. This proposal aims to reduce this bottleneck of information flow with the purchase of a suite of newly-available, automated, high throughput technologies that will provide a combination of fast, cutting-edge approaches to accelerate research at the genome-phenome nexus, and allow an integrated view of the living cell.

Publications:

O'Rourke, MB, Djordjevic, SP & Padula, MP 2018, 'The Quest for Improved Reproducibility In MALDI Mass Spectrometry', Mass Spectrometry Reviews, vol. 37, no. 2, pp. 217-228.
View/Download from: UTS OPUS or Publisher's site

Wyrsch, E, Roy Chowdhury, P, Chapman, TA, Charles, IG, Hammond, JM & Djordjevic, SP 2016, 'Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis', Frontiers in Microbiology, vol. 7, no. 843.
View/Download from: UTS OPUS or Publisher's site

Keywords: genomics,phenomics,systems biology

FOR Codes: Biochemistry and Cell Biology not elsewhere classified, Infectious Diseases, Systems Biology, Expanding Knowledge in the Biological Sciences, Bioinformatics, Cancer and Related Disorders