Novel Omega-3 Fatty Acid Analogues for Treatment of Breast and Secondary Brain Cancers

Project Member(s): Rawling, T.

Start year: 2013

Summary: Stipend Activity Code: 2049010

Publications:

Rawling, T, MacDermott-Opeskin, H, Roseblade, A, Pazderka, C, Clarke, C, Bourget, K, Wu, X, Lewis, W, Noble, B, Gale, PA, O'Mara, ML, Cranfield, C & Murray, M 2020, 'Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter', Chemical Science, vol. 11, no. 47, pp. 12677-12685.
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Al-Zubaidi, Y, Pazderka, C, Koolaji, N, Rahman, MK, Choucair, H, Umashankar, B, Bourget, K, Chen, Y, Rawling, T & Murray, M 2019, 'Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells', European Journal of Pharmaceutical Sciences, vol. 129, pp. 87-98.
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Koolaji, N, Rawling, T, Bourget, K & Murray, M 2018, 'Carboxylate Analogues of Aryl‐Urea‐Substituted Fatty Acids That Target the Mitochondria in MDA‐MB‐231 Breast Cancer Cells to Promote Cell Death', ChemMedChem, vol. 13, no. 10, pp. 1036-1043.
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Murray, M, Choucair, H, Allison, S, Bourget, K, Chen, Y, Dunstan, C & Rawling, T 2017, 'O25 A novel synthetic ω-3 fatty acid epoxide analogue activates breast cancer cell killing in vitro and in vivo', Biochemical Pharmacology, vol. 139, pp. 117-117.
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Koolaji, N, Murray, M & Rawling, T 1970, 'Aryl group modification in novel anti-cancer agents based on ω-3-17,18-epoxyeicosapentaenoic acid', European Journal of Cancer, 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Elsevier BV, Munich, GERMANY, pp. S68-S68.
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FOR Codes: Pharmacology and Pharmaceutical Sciences

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.