Sino-Australian cooperative study on the forensic toxicokinetics of the metabolite MEGX of Lidocaine

Project Member(s): Fu, S.

Funding or Partner Organisation: Shanxi Science and Technology Bureau

Start year: 2012

Summary: Lidocaine was commonly used for epidural anesthesia in clinic. There is an escalating trend of the epidural anesthesia accident in China. It is difficult to determine the way by which the poison enters the body. Our previous study has exhibited that the postmortem distribution, dynamic distribution of Lidocaine can be used for determining the way by which the poison enters the body, but it should be determined first when Lidocaine enters the body. In this study, the animal models will be used to assess of the forensic toxicokinetics such as toxicokinetics, postmortem distribution, dynamic distribution, postmortem redistribution, postmortem diffusion of the metabolite MEGX of Lidocaine in epidural anesthesia accident dogs. By the ratio of lidocaine metabolite to parent and postmortem diffusion of lidocaine metabolit, it will be solved to to distinguish the poisons which were given before the death or produced after the death and to determine the time when the poison enters the body.

Publications:

Wei, Z, Niu, Q, Zhang, F, Xiao, K, Liu, L, Wang, Y, Jia, J, Cao, J, Fu, S & Yun, K 2017, 'The effect of sodium fluoride, formaldehyde, and storage temperature on the stability of methamidophos in post-mortem blood and liver', International Journal of Legal Medicine, vol. 131, no. 3, pp. 667-675.
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Keywords: lidocaine, toxicokinetics, postmortem distribution

FOR Codes: Toxicology (incl. Clinical Toxicology), Expanding Knowledge in the Chemical Sciences, Toxicology (incl. clinical toxicology)