Investigation of the HMGB1-RAGE axis in airway wall remodelling in asthma

Funding or Partner Organisation: Asthma Australia Inc

Start year: 2013

Summary: Hypothesis: HMGB1 and RAGE are critical to the process of airway remodelling in asthma Aim 1: To establish the role of HMGB1 and RAGE in the development of airway remodelling in a chronic mouse model of allergen-induced asthma Aim 2: To determine molecular mechanisms by which HMGB1 and RAGE induce remodelling responses in airway epithelial and smooth muscle cells. Aim 3: To determine whether gene-gene interactions between RAGE and HMGB1 and putative pathways are related to severity and subphenotypes of asthma associated with remodelling.

Publications:

Gold, MJ, Hiebert, PR, Park, HY, Stefanowicz, D, Le, A, Starkey, MR, Deane, A, Brown, AC, Liu, G, Horvat, JC, Ibrahim, ZA, Sukkar, MB, Hansbro, PM, Carlsten, C, VanEeden, S, Sin, DD, McNagny, KM, Knight, DA & Hirota, JA 2016, 'Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization', MUCOSAL IMMUNOLOGY, vol. 9, no. 3, pp. 809-820.
View/Download from: Publisher's site

Wong, S, Ibrahim, Z, Wark, P & Sukkar, M 2015, 'SPARC: A DOWN-STREAM MEDIATOR OF TGF-BETA; WHICH MAY POTENTIALLY PLAY A ROLE IN CHRONIC AIRWAYS DISEASE', WILEY-BLACKWELL, pp. 144-144.

Keywords: asthma, allergy, remodeling, HMGB1, RAGE, GWAS, epithelium, airway smooth muscle

FOR Codes: Respiratory Diseases, Respiratory System and Diseases (incl. Asthma), Respiratory diseases , Clinical health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.