Investigation of the HMGB1-RAGE axis in airway wall remodelling in asthma

Project Member(s): Sukkar, M.

Funding or Partner Organisation: Asthma Australia Inc

Start year: 2013

Summary: Hypothesis: HMGB1 and RAGE are critical to the process of airway remodelling in asthma Aim 1: To establish the role of HMGB1 and RAGE in the development of airway remodelling in a chronic mouse model of allergen-induced asthma Aim 2: To determine molecular mechanisms by which HMGB1 and RAGE induce remodelling responses in airway epithelial and smooth muscle cells. Aim 3: To determine whether gene-gene interactions between RAGE and HMGB1 and putative pathways are related to severity and subphenotypes of asthma associated with remodelling.

Publications:

Gold, MJ, Hiebert, PR, Park, HY, Stefanowicz, D, Le, A, Starkey, MR, Deane, A, Brown, AC, Liu, G, Horvat, JC, Ibrahim, ZA, Sukkar, MB, Hansbro, PM, Carlsten, C, VanEeden, S, Sin, DD, McNagny, KM, Knight, DA & Hirota, JA 2016, 'Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.', Mucosal Immunology, vol. 9, no. 3, pp. 809-820.
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Wong, S, Ibrahim, Z, Wark, P & Sukkar, M 2015, 'SPARC: A DOWN-STREAM MEDIATOR OF TGF-BETA; WHICH MAY POTENTIALLY PLAY A ROLE IN CHRONIC AIRWAYS DISEASE', RESPIROLOGY, Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015, WILEY-BLACKWELL, Queensland, AUSTRALIA, pp. 144-144.

Keywords: asthma, allergy, remodeling, HMGB1, RAGE, GWAS, epithelium, airway smooth muscle

FOR Codes: Respiratory Diseases, Respiratory System and Diseases (incl. Asthma)