Understanding and predicting freezing of gait in Parkinson's Disease

Project Member(s): Nguyen, H.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC Project Grant starting in 2000)

Start year: 2014

Summary: Freezing of Gait (FOG) affects half of all patients with Parkinson¿s Disease (PD) with episodes causing the feet to feel glued to the ground leading to a significant falls risk. The mechanisms underlying FOG are not well understood and current treatments are usually ineffective. Combining brain wave recording, eye-tracking and functional brain scanning we will identify the changes that precipitate an episode of FOG allowing the development of a non-invasive device to prevent falls.

Publications:

Ly, QT, Handojoseno, AMA, Gilat, M, Chai, R, Ehgoetz Martens, KA, Georgiades, M, Naik, GR, Tran, Y, Lewis, SJG & Nguyen, HT 1970, 'Detection of gait initiation Failure in Parkinson's disease based on wavelet transform and Support Vector Machine', 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Jeju Island, Korea, pp. 3048-3051.
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Ly, QT, Handojoseno, AMA, Gilat, M, Chai, R, Ehgoetz Martens, KA, Georgiades, M, Naik, GR, Tran, Y, Lewis, SJG & Nguyen, HT 1970, 'Detection of turning freeze in Parkinson's disease based on S-transform decomposition of EEG signals', 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Jeju Island, Korea, pp. 3044-3047.
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Ly, QT, Handojoseno, AMA, Gilat, M, Nguyen, N, Chai, R, Tran, Y, Lewis, SJG & Nguyen, HT 1970, 'Detection of Gait Initiation Failure in Parkinson's disease patients using EEG signals', 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Orlando, USA, pp. 1599-1602.
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Ly, QT, Handojoseno, AMA, Gilat, M, Nguyen, N, Chai, R, Tran, Y, Lewis, SJG & Nguyen, HT 1970, 'Identifying montages that best detect the electroencephalogram power spectrum alteration during freezing of gait in Parkinson's disease patients', 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Orlando, USA, pp. 6094-6097.
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Handojoseno, AMA, Shine, JM, Nguyen, TN, Tran, Y, Lewis, SJG & Nguyen, HT 2015, 'Analysis and Prediction of the Freezing of Gait Using EEG Brain Dynamics', IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 23, no. 5, pp. 887-896.
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Handojoseno, AMA, Gilat, M, Quynh Tran Ly, Chamtie, H, Shine, JM, Nguyen, TN, Tran, Y, Lewis, SJG & Nguyen, HT 1970, 'An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex', 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Milano, Italy, pp. 6618-6621.
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Shine, JM, Handojoseno, AMA, Nguyen, TN, Tran, Y, Naismith, SL, Nguyen, H & Lewis, SJG 2014, 'Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in Parkinson’s disease', Clinical Neurophysiology, vol. 125, no. 3, pp. 569-576.
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Ardi Handojoseno, AM, Shine, JM, Gilat, M, Nguyen, TN, Tran, Y, Lewis, SJG & Nguyen, HT 1970, 'Prediction of freezing of gait using analysis of brain effective connectivity', 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Chicago, Illinois, USA, pp. 4119-4122.
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Keywords: Parkinson disease, neuroimaging, electroencephalography, biomechanics, falls prevention

FOR Codes: Neurology and Neuromuscular Diseases, Biomedical Instrumentation, Medical Instruments, Neurodegenerative Disorders Related to Ageing, Instrumentation, Clinical health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.