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Molecular characterisation of antibiotic resistance genes in Salmonella enterica and Escherichia coli recovered from food-producing animals and humans

Funding: 2003: $23,033
2004: $46,066
2005: $46,066
2006: $23,033

Project Member(s): Djordjevic, S.

Funding or Partner Organisation: NSW Agriculture
Australian Research Council (ARC Linkage Projects)

Start year: 2003

Summary: Antibiotic resistance is an accelerating global problem. Antibiotic resistance genes are located on mobile genetic elements which can be horizontally transferred between distantly related bacteria. It is becoming increasingly apparent that healthy humans carry populations of resistant bacteria as part of the normal microbial flora. This project will characterise the antibiotic resistance gene arrangements among populations of bacteria which belong to the Enterobacteriaceae. These resistant bacteria represent a threat to human and veterinary health because they are readily ingested as part of the food chain and represent reservoirs for the spread of antibiotic resistance genes to pathogens


O'Rourke, MB, Djordjevic, SP & Padula, MP 2018, 'The quest for improved reproducibility in MALDI mass spectrometry', Mass Spectrometry Reviews, vol. 37, no. 2, pp. 217-228.
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Wyrsch, ER, Roy Chowdhury, P, Chapman, TA, Charles, IG, Hammond, JM & Djordjevic, SP 2016, 'Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis', Frontiers in Microbiology, vol. 7, no. JUN.
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Venturini, C, Hassan, KA, Roy Chowdhury, P, Paulsen, IT, Walker, MJ & Djordjevic, SP 2013, 'Sequences of Two Related Multiple Antibiotic Resistance Virulence Plasmids Sharing a Unique IS26-Related Molecular Signature Isolated from Different Escherichia coli Pathotypes from Different Hosts', PLoS ONE, vol. 8, no. 11, pp. e78862-e78862.
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FOR Codes: Microbiology