A helminth-derived peptide is a novel prohpylactic and therapeutic treatment for autoimmune diabetes

Project Member(s): Donnelly, S., O'Brien, B., Simpson, A.

Funding or Partner Organisation: National Health & Medical Research Council (National Health Medical Research Council)

Start year: 2015

Summary: We will investigate the ability of a helminth-derived peptide to inhibit the presentation of allo and auto-antigen to T cells and therefore prevent the initiation of immune-mediated disease and transplant rejection

Publications:

Tanaka, A, Allam, VSRR, Simpson, J, Tiberti, N, Shiels, J, To, J, Lund, M, Combes, V, Weldon, S, Taggart, C, Dalton, JP, Phipps, S, Sukkar, MB & Donnelly, S 2018, 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma', Journal of Allergy and Clinical Immunology, vol. 141, no. 6, pp. 2316-2319.
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Alvarado, R, To, J, Lund, ME, Pinar, A, Mansell, A, Robinson, MW, O'Brien, BA, Dalton, JP & Donnelly, S 2017, 'The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages', The FASEB Journal, vol. 31, no. 1, pp. 85-95.
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Lund, ME, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, AT, Robinson, MW, Simpson, AM, O’Brien, BA, Dalton, JP & Donnelly, S 2016, 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis', Scientific Reports, vol. 6, no. 1, pp. 1-11.
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Lund, ME, To, J, O'Brien, BA & Donnelly, S 2016, 'The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus', JOURNAL OF IMMUNOLOGICAL METHODS, vol. 430, pp. 64-70.
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FOR Codes: Medical Microbiology not elsewhere classified, Diabetes, Clinical health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.