A helminth-derived peptide is a novel prohpylactic and therapeutic treatment for autoimmune diabetes
Project Member(s): Donnelly, S., O'Brien, B., Simpson, A.
Funding or Partner Organisation: National Health & Medical Research Council (National Health Medical Research Council)
Start year: 2015
Summary: We will investigate the ability of a helminth-derived peptide to inhibit the presentation of allo and auto-antigen to T cells and therefore prevent the initiation of immune-mediated disease and transplant rejection
Publications:
Tanaka, A, Allam, VSRR, Simpson, J, Tiberti, N, Shiels, J, To, J, Lund, M, Combes, V, Weldon, S, Taggart, C, Dalton, JP, Phipps, S, Sukkar, MB & Donnelly, S 2018, 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma', Elsevier BV, pp. 2316-2319.
View/Download from: Publisher's site
Alvarado, R, To, J, Lund, ME, Pinar, A, Mansell, A, Robinson, MW, O'Brien, BA, Dalton, JP & Donnelly, S 2017, 'The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages', The FASEB Journal, vol. 31, no. 1, pp. 85-95.
View/Download from: Publisher's site
Lund, ME, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, AT, Robinson, MW, Simpson, AM, O’Brien, BA, Dalton, JP & Donnelly, S 2016, 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis', Scientific Reports, vol. 6, no. 1, pp. 1-11.
View/Download from: Publisher's site
Lund, ME, To, J, O'Brien, BA & Donnelly, S 2016, 'The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus', JOURNAL OF IMMUNOLOGICAL METHODS, vol. 430, pp. 64-70.
View/Download from: Publisher's site
FOR Codes: Medical Microbiology not elsewhere classified, Diabetes, Clinical health