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A helminth-derived peptide is a novel prohpylactic and therapeutic treatment for autoimmune diabetes

Project Member(s): Donnelly, S., O'Brien, B., Simpson, A.

Funding or Partner Organisation: National Health & Medical Research Council (National Health Medical Research Council)

Start year: 2015

Summary: We will investigate the ability of a helminth-derived peptide to inhibit the presentation of allo and auto-antigen to T cells and therefore prevent the initiation of immune-mediated disease and transplant rejection

Publications:

Tanaka, A, Allam, VSRR, Simpson, J, Tiberti, N, Shiels, J, To, J, Lund, M, Combes, V, Weldon, S, Taggart, C, Dalton, JP, Phipps, S, Sukkar, MB & Donnelly, S 2018, 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma', Journal of Allergy and Clinical Immunology, vol. 141, no. 6, pp. 2316-2319.
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Alvarado, R, To, J, Lund, ME, Pinar, A, Mansell, A, Robinson, MW, O'Brien, BA, Dalton, JP & Donnelly, S 2017, 'The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages', The FASEB Journal, vol. 31, no. 1, pp. 85-95.
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Lund, ME, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, AT, Robinson, MW, Simpson, AM, O’Brien, BA, Dalton, JP & Donnelly, S 2016, 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis', Scientific Reports, vol. 6, no. 1, pp. 1-11.
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Lund, ME, To, J, O'Brien, BA & Donnelly, S 2016, 'The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus', JOURNAL OF IMMUNOLOGICAL METHODS, vol. 430, pp. 64-70.
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FOR Codes: Medical Microbiology not elsewhere classified, Diabetes, Clinical health