The role of central carbon metabolism in cell cycle control in bacteria

Funding: 2015: $145,000
2016: $128,500
2017: $140,000

Project Member(s): Harry, E.

Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)

Start year: 2015

Summary: Bacteria are simple organisms. Yet we still do not understand how they coordinate their growth with their reproduction so faithfully, generation after generation, to produce viable newborn cells. Our new discovery of a link between the food they eat and the first stage of cell division in bacteria now provides the opportunity to elucidate how they `measure¿ their energy production to control their proliferation. This project combines the latest technology with complementary expertise in bacterial cell division and metabolism to identify the mechanism that integrates these fundamental pathways in bacteria, crucial to their survival and ability to cause infection.

Publications:

Kusuma, KD, Payne, M, Ung, AT, Bottomley, AL & Harry, EJ 2019, 'FtsZ as an Antibacterial Target: Status and Guidelines for Progressing This Avenue', ACS Infectious Diseases, vol. 5, no. 8, pp. 1279-1294.
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Mann, R, Mediati, DG, Duggin, IG, Harry, EJ & Bottomley, AL 2017, 'Metabolic Adaptations of Uropathogenic E. coli in the Urinary Tract', Frontiers in Cellular and Infection Microbiology, vol. 7, no. JUN, pp. 1-15.
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Monahan, LG & Harry, EJ 2016, 'You Are What You Eat: Metabolic Control of Bacterial Division', TRENDS IN MICROBIOLOGY, vol. 24, no. 3, pp. 181-189.
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Keywords: cell division, bacteria, bacterial genetics

FOR Codes: Bacteriology, Microbial Genetics, Expanding Knowledge in the Biological Sciences, Expanding Knowledge in Technology, Bacteriology , Microbial genetics , EXPANDING KNOWLEDGE

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.