Metalloproteomics: A new piece of the systems biology puzzle

Funding: 2015: $69,352
2016: $81,988
2017: $78,620

Project Member(s): Hare, D.

Funding or Partner Organisation: Australian Research Council (ARC Linkage Projects)
Agilent Technologies (Agilent Technologies Australia Pty Ltd)
The Florey Institute of Neuroscience and Mental Health

Start year: 2015

Summary: Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the result of chemical reactions involving metalloproteins, which are notoriously difficult to study due to the weak bonds between metal and protein that is not normally amenable to traditional proteomic approaches. In partnership with the leading analytical manufacturer Agilent Technologies, we will adapt and apply advanced mass spectrometry to the study of metalloproteins, developing new methods for studying hundreds of molecules in single experiments. Using the C. elegans model organism, we will showcase the importance of metals in biology and develop new solutions for the $2.9 billion proteomics industry.

Publications:

Hare, DJ & New, EJ 2016, 'On the outside looking in: redefining the role of analytical chemistry in the biosciences', Chemical Communications, vol. 52, no. 58, pp. 8918-8934.
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Hare, DJ, Raven, EP, Roberts, BR, Bogeski, M, Portbury, SD, McLean, CA, Masters, CL, Connor, JR, Bush, AI, Crouch, PJ & Doble, PA 2016, 'Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex', NeuroImage, vol. 137, pp. 124-131.
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Keywords: metalloproteomics, systems biology, mass spectrometry

FOR Codes: Analytical Biochemistry, Systems Biology, Expanding Knowledge in the Biological Sciences, Expanding Knowledge in the Chemical Sciences

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.