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Detection and analysis of new designer drugs

Project Member(s): Fu, S.

Funding or Partner Organisation: NSW Forensic and Analytical Science Service

Start year: 2014

Summary: New drugs of abuse are emerging in the illicit drug market all the time. It is challenging for the law enforcement authorities to detect and identify the supply and use of these new designer drugs. This study aims to develop effective analytical methods to detect and identify these new chemical identities as they emerge. The study also aims to investigate the metabolic pathways of the drugs and elucidate the structures of the major metabolites so to provide leads for drug testing laboratory to develop new methods to monitor the use of these drugs of abuse.

Publications:

Watanabe, S, Kuzhiumparambil, U & Fu, S 2018, 'In vitro metabolism of synthetic cannabinoid AM1220 by human liver microsomes and Cunninghamella elegans using liquid chromatography coupled with high resolution mass spectrometry', FORENSIC TOXICOLOGY, vol. 36, no. 2, pp. 435-446.
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Watanabe, S, Kuzhiumparambil, U & Fu, S 2018, 'Structural Elucidation of Metabolites of Synthetic Cannabinoid UR-144 by Cunninghamella elegans Using Nuclear Magnetic Resonance (NMR) Spectroscopy.', The AAPS journal, vol. 20, no. 2.
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Pasin, D, Cawley, A, Bidny, S & Fu, S 2017, 'Characterization of hallucinogenic phenethylamines using high-resolution mass spectrometry for non-targeted screening purposes', DRUG TESTING AND ANALYSIS, vol. 9, no. 10, pp. 1620-1629.
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Pasin, D, Cawley, A, Bidny, S & Fu, S 2017, 'Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review', ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 409, no. 25, pp. 5821-5836.
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Watanabe, S, Kuzhiumparambil, U, Nguyen, MA, Cameron, J & Fu, S 2017, 'Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 by Cunninghamella elegans.', The AAPS Journal, vol. 19, no. 4, pp. 1148-1162.
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Watanabe, S, Kuzhiumparambil, U, Winiarski, Z & Fu, S 2016, 'Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans', Forensic Science International, vol. 261, pp. 33-42.
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Keywords: Designer drugs, metabolism, drug testing, forensic chemistry, forensic toxicology

FOR Codes: Diagnostic Methods, Toxicology (incl. Clinical Toxicology)