NHMRC - Myopia: gene-environment interactions
Project Member(s): Rose, K.
Funding or Partner Organisation: National Health & Medical Research Council (NHMRC Project Grants)
Start year: 2014
Summary: Sydney Childhood Eye Study has a comprehensive database on ocular development in children. Baseline phenotypic data were collected on over 1700 Year 1 students (6-7 years) and over 2300 Year 7 students (12-13 years) with follow-up data collected 5 years later (2008-2010). All participants received a comprehensive eye examination and completed a questionnaire to collect estimates of time children spend on near work and outdoors, and family socio-demographic and health information. These studies have made major contributions in two areas of complex disease, myopic refractive error and retinal vascular changes associated with childhood obesity and sedentary behaviour. The primary aim of this project is to collect DNA samples to complement the existing comprehensive phenotypic and risk factor database.
Publications:
He, X, Sankaridurg, P, Wang, J, Chen, J, Naduvilath, T, He, M, Zhu, Z, Li, W, Morgan, IG, Xiong, S, Zhu, J, Zou, H, Rose, KA, Zhang, B, Weng, R, Resnikoff, S & Xu, X 2022, 'Time Outdoors in Reducing Myopia', Ophthalmology, vol. 129, no. 11, pp. 1245-1254.
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Tang, SM, Kam, KW, French, AN, Yu, M, Chen, LJ, Young, AL, Rose, KA, Tham, CC, Pang, CP & Yam, JC 2022, 'Erratum to Independent Influence of Parental Myopia on Childhood Myopia in a Dose-Related Manner in 2,055 Trios: The Hong Kong Children Eye Study (Am J Ophthalmol 2020;218:199–207)', American Journal of Ophthalmology, vol. 240, pp. 353-353.
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Lingham, G, Yazar, S, Lucas, RM, Milne, E, Hewitt, AW, Hammond, CJ, MacGregor, S, Rose, KA, Chen, FK, He, M, Guggenheim, JA, Clarke, MW, Saw, S-M, Williams, C, Coroneo, MT, Straker, L & Mackey, DA 2021, 'Time spent outdoors in childhood is associated with reduced risk of myopia as an adult', Scientific Reports, vol. 11, no. 1, pp. 1-11.
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Morgan, IG, Wu, P-C, Ostrin, LA, Tideman, JWL, Yam, JC, Lan, W, Baraas, RC, He, X, Sankaridurg, P, Saw, S-M, French, AN, Rose, KA & Guggenheim, JA 2021, 'IMI Risk Factors for Myopia', Investigative Opthalmology & Visual Science, vol. 62, no. 5, pp. 3-3.
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Gifford, KL, Richdale, K, Kang, P, Aller, TA, Lam, CS, Liu, YM, Michaud, L, Mulder, J, Orr, JB, Rose, KA, Saunders, KJ, Seidel, D, Tideman, JWL & Sankaridurg, P 2019, 'IMI – Clinical Management Guidelines Report', Investigative Opthalmology & Visual Science, vol. 60, no. 3, pp. M184-M184.
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Jiang, X, Tarczy-Hornoch, K, Stram, D, Katz, J, Friedman, DS, Tielsch, JM, Matsumura, S, Saw, S-M, Mitchell, P, Rose, KA, Cotter, SA & Varma, R 2019, 'Prevalence, Characteristics, and Risk Factors of Moderate or High Hyperopia among Multiethnic Children 6 to 72 Months of Age', Ophthalmology, vol. 126, no. 7, pp. 989-999.
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Morgan, IG & Rose, KA 2019, 'Myopia: is the nature‐nurture debate finally over?', Clinical and Experimental Optometry, vol. 102, no. 1, pp. 3-17.
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Morgan, IG, French, AN & Rose, K 2019, 'Myopia in low-resource settings.', Community Eye Health, vol. 32, no. 105, pp. 11-11.
Morgan, IG, French, AN & Rose, KA 2018, 'Intense schooling linked to myopia', BMJ, vol. 361, pp. k2248-k2248.
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Morgan, IG, He, M & Rose, KA 2017, 'EPIDEMIC OF PATHOLOGIC MYOPIA', Retina, vol. 37, no. 5, pp. 989-997.
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Morgan, IG, French, A & Rose, KA 1970, 'SCHOOL SYSTEMS WITH A HIGH PREVALENCE OF MYOPIA DOMINATE INTERNATIONAL COMPARISONS IN MATHS AND SCIENCE', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) - Imaging in the Eye, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD.
French, AN, Morgan, IG & Rose, KA 1970, 'Risk factors for longitudinal biometric and refractive change in Australian schoolchildren', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ASSOC RESEARCH VISION OPHTHALMOLOGY INC, WA, Seattle.
Wang, J, Sankaridurg, P, Naduvilath, T, Li, W, Morgan, IG, Rose, KA, Weng, R, Xu, X & He, X, 'Time outdoors positively associates with academic performance: a school-based study with objective monitoring of outdoor time', BMC Public Health, vol. 23, no. 1.
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Keywords: Myopia, genes, environment, childhood
FOR Codes: Ophthalmology, Vision Science, Hearing, Vision, Speech and Their Disorders, Clinical health