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NHMRC - Myopia: gene-environment interactions

Project Member(s): Rose, K.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC Project Grants)

Start year: 2014

Summary: Sydney Childhood Eye Study has a comprehensive database on ocular development in children. Baseline phenotypic data were collected on over 1700 Year 1 students (6-7 years) and over 2300 Year 7 students (12-13 years) with follow-up data collected 5 years later (2008-2010). All participants received a comprehensive eye examination and completed a questionnaire to collect estimates of time children spend on near work and outdoors, and family socio-demographic and health information. These studies have made major contributions in two areas of complex disease, myopic refractive error and retinal vascular changes associated with childhood obesity and sedentary behaviour. The primary aim of this project is to collect DNA samples to complement the existing comprehensive phenotypic and risk factor database.

Publications:

Gifford, KL, Richdale, K, Kang, P, Aller, TA, Lam, CS, Liu, YM, Michaud, L, Mulder, J, Orr, JB, Rose, KA, Saunders, KJ, Seidel, D, Tideman, JWL & Sankaridurg, P 2019, 'IMI - Clinical Management Guidelines Report.', Investigative ophthalmology & visual science, vol. 60, no. 3, pp. M184-M203.
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Jiang, X, Tarczy-Hornoch, K, Stram, D, Katz, J, Friedman, DS, Tielsch, JM, Matsumura, S, Saw, S-M, Mitchell, P, Rose, KA, Cotter, SA, Varma, R & Population-Based Pediatric Eye Disease Study Consortium 2019, 'Prevalence, Characteristics, and Risk Factors of Moderate or High Hyperopia among Multiethnic Children 6 to 72 Months of Age: A Pooled Analysis of Individual Participant Data.', Ophthalmology, vol. 126, no. 7, pp. 989-999.
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Morgan, IG & Rose, KA 2019, 'Myopia: is the nature-nurture debate finally over?', Clinical and Experimental Optometry, vol. 102, no. 1, pp. 3-17.
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Morgan, I, French, AN & Rose, K 2018, 'Intense schooling linked to myopia', BMJ, vol. 361.
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Morgan, IG, He, M & Rose, KA 2017, 'EPIDEMIC OF PATHOLOGIC MYOPIA: What Can Laboratory Studies and Epidemiology Tell Us?', RETINA, vol. 37, no. 5, pp. 989-997.
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Morgan, IG, French, AN & Rose, K 2017, 'SCHOOL SYSTEMS WITH A HIGH PREVALENCE OF MYOPIA DOMINATE INTERNATIONAL COMPARISONS IN MATHS AND SCIENCE', Investigative Ophthalmology & Visual Science, The Association for Research in Vision and Ophthalmology Annual Meeting, Association for Research in Vision and Ophthalmology, Baltimore, MD.

French, AN, Morgan, IG & Rose, K 2016, 'Risk factors for longitudinal biometric and refractive change in Australian schoolchildren', Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology Annual Meeting, Association for Research in Vision and Ophthalmology, Seattle, Washington.
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Keywords: Myopia, genes, environment, childhood

FOR Codes: Ophthalmology, Vision Science, Hearing, Vision, Speech and Their Disorders