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A systems biology capability for the Ramaciotti Centre for Genomics - (LE160100204 - led by USyd)

Funding: 2016: $116,954

Project Member(s): Djordjevic, S., Myers, G., McDougald, S.

Funding or Partner Organisation: Australian Research Council (ARC Linkage Infrastructure)

Start year: 2016

Summary: The Ramaciotti Centre for Genomics (RCG) is a consortium of NSW-based universities and research institutes. It is the technical focus for genomics and transcriptomics expertise in NSW. This LIEF proposal requests equipment to enable the RCG to provide a complete systems biology workflow, including improved data analysis for Illumina sequencing, tissue preparation and imaging, and mass spectrometry for proteomics and metabolomics. If funded, this will be the first suite of equipment provided by a service facility in Australia that enables a truly systems approach to biological problems. It will be used by the CIs, and the wider user base of the Centre, to facilitate cutting-edge research discoveries using high-throughput technologies. Impact statement The project will introduce a complete systems biology capability to a diverse research community in the state of New South Wales. It will support projects that focus on microbial and mammalian metabolism, carbohydrate chemistry, and synthetic biology. It will enable the Ramaciotti Centre for Genomics to provide a complete suite of systems biology tools to its user base of >350 labs, and thus capture the new cutting edge in this fast-moving field.

Publications:

O'Rourke, MB, Djordjevic, SP & Padula, MP 2018, 'The Quest for Improved Reproducibility In MALDI Mass Spectrometry', Mass Spectrometry Reviews, vol. 37, no. 2, pp. 217-228.
View/Download from: UTS OPUS or Publisher's site

Wyrsch, E, Roy Chowdhury, P, Chapman, TA, Charles, IG, Hammond, JM & Djordjevic, SP 2016, 'Genomic Microbial Epidemiology Is Needed to Comprehend the Global Problem of Antibiotic Resistance and to Improve Pathogen Diagnosis', Frontiers in Microbiology, vol. 7, no. 843.
View/Download from: UTS OPUS or Publisher's site

FOR Codes: Systems Biology, Proteomics and Intermolecular Interactions (excl. Medical Proteomics), Genomics, Expanding Knowledge in the Biological Sciences