Novel BMSC delivery of combination gene therapy for treatment-resistant metastatic prostate cancer: Non-invasive molecular and functional imaging in immune intact mouse models.

Funding or Partner Organisation: Sydney Vital (Sydney Vital Flagship 1 Seed Funding)

Start year: 2015

Summary: Prostate cancer (PCa) seeking adult stem cells (BMSC) will be engineered to produce a secreted factor that kills PCa by the stimulation of the immune system and a suicide factor. The suicide factor may be "switched on" with a prodrug to further destroy nearby tumour cells. Together, this will produce a BMSC therapeutic factory for infusion into the bloodstream to "seek and destroy" PCa anywhere in the body. This study will provide a novel treatment for treatment resistant metastatic PCa which is currently incurable.

Publications:

Gerace, D, Martiniello-Wilks, R, Habib, R & Simpson, AM 2019, 'Luciferase-based reporting of suicide gene activity in murine mesenchymal stem cells', PLOS ONE, vol. 14, no. 7, pp. e0220013-e0220013.
View/Download from: Publisher's site

Habib, R, Brennan, S, Tan, M, Larsen, SR & Martiniello-Wilks, R 1970, 'UNDERSTANDING AND HARNESSING MESENCHYMAL STEM CELL HOMING TO METASTATIC PROSTATE CANCER', JOURNAL OF GENE MEDICINE, 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), WILEY-BLACKWELL, Univ Melbourne, Univ Coll, Parkville, AUSTRALIA, pp. 200-201.

Suurbach, JH, Habib, R, Brennan, S, Larsen, SR, Simpson, A & Martiniello-Wilks, R 1970, 'CELLULAR AND GENETIC MEDICINES ADVANCING THE TREATMENT OF METASTATIC PROSTATE CANCER', JOURNAL OF GENE MEDICINE, 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), WILEY-BLACKWELL, Univ Melbourne, Univ Coll, Parkville, AUSTRALIA, pp. 198-199.

Keywords: Prostate Cancer, gene therapy, adult stem cells

FOR Codes: Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Men's Health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.