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Interactions between aberrant transcriptional programs and methylation in primary myelodysplasia and leukaemia

Project Member(s): Beck, D.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC Early Career Fellowships)

Start year: 2015

Summary: Interactions between aberrant transcriptional programs and methylation in primary myelodysplasia and leukaemia

Publications:

Kumar, P, Beck, D, Galeev, R, Thoms, JAI, Talkhoncheh, MS, de Jong, I, Unnikrishnan, A, Baudet, A, Subramaniam, A, Pimanda, JE & Larsson, J 2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood advances, vol. 3, no. 4, pp. 681-691.
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Beck, D, Thoms, JAI, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, BJ, Schwarzer, A, Klusmann, J-H, Berdel, WE, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, SK, To, LB, Scott, HS, Lewis, ID, D'Andrea, RJ, Wong, JWH & Pimanda, JE 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.', Leukemia, vol. 32, no. 2, pp. 263-272.
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Chiu, SK, Saw, J, Huang, Y, Sonderegger, SE, Wong, NC, Powell, DR, Beck, D, Pimanda, JE, Tremblay, CS & Curtis, DJ 2018, 'A novel role for Lyl1 in primitive erythropoiesis', DEVELOPMENT, vol. 145, no. 19.
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Jing, D, Huang, Y, Liu, X, Sia, KCS, Zhang, JC, Tai, X, Wang, M, Toscan, CE, McCalmont, H, Evans, K, Mayoh, C, Poulos, RC, Span, M, Mi, J, Zhang, C, Wong, JWH, Beck, D, Pimanda, JE & Lock, RB 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', CANCER CELL, vol. 34, no. 6, pp. 906-+.
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Liu, Q, Thoms, JAI, Nunez, AC, Huang, Y, Knezevic, K, Packham, D, Poulos, RC, Williams, R, Beck, D, Hawkins, NJ, Ward, RL, Wong, JWH, Hesson, LB, Sloane, MA & Pimanda, JE 2018, 'Disruption of a-35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells', CLINICAL CANCER RESEARCH, vol. 24, no. 18, pp. 4602-4611.
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Liu, K, Beck, D, Thoms, JAI, Liu, L, Zhao, W, Pimanda, JE & Zhou, X 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics (Oxford, England), vol. 33, no. 17, pp. 2622-2630.
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Schwarzer, A, Emmrich, S, Schmidt, F, Beck, D, Ng, M, Reimer, C, Adams, FF, Grasedieck, S, Witte, D, Käbler, S, Wong, JWH, Shah, A, Huang, Y, Jammal, R, Maroz, A, Jongen-Lavrencic, M, Schambach, A, Kuchenbauer, F, Pimanda, JE, Reinhardt, D, Heckl, D & Klusmann, J-H 2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia.', Nature Communications, vol. 8, no. 1, pp. 1-17.
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Beck, D, Thoms, J, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, B, Berdel, W, Woermann, B, Buechner, T, Hiddemann, W, Bohlander, S, Scott, H, Lewis, I, D'Andrea, R, Wong, J & Pimanda, J 2016, 'Integrative analysis of lincrna expression in 922 acute myeloid leukemia patients reveals multiple prognostic gene signatures', Haematologica, pp. 208-209.

FOR Codes: Bioinformatics, Blood Disorders, Cancer and Related Disorders