ARC Research Hub for Integrated Device for End-user Analysis at Low-levels

Funding: 2016: $1,110,258
2017: $749,114
2018: $736,665
2019: $740,334
2020: $372,140

Project Member(s): Valenzuela, S., Jin, D., Aharonovich, I., Fu, S., Cranfield, C., Shimoni, O., Care, A.

Funding or Partner Organisation: University of South Australia
Australian Research Council (ARC Industrial Transformation Research Hubs)
Surgical Diagnostics Pty Limited
Alcolizer Pty Ltd (Alcolizer Technology)
Preg Tech Pty Ltd
Minomic International Ltd
ULVAC Singapore Pte Ltd (Ulvac)
Indee Pty Ltd

Start year: 2017

Summary: By transforming Australian advances in biomolecular science, nanotechnology and device engineering into highvalue products, the Hub aims to radically improve sensitivity, selectivity, speed and cost for detection of biological materials. The mission is to build a portable device for rapid, time-critical detection of low abundance molecular and cellular analytes. The resulting technologies will be designed for use on the production line, at the clinic, bedside, roadside and transport points to identify tiny levels of targeted molecules. The initial focus is early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins, for example. IMPACT STATEMENT: This ARC Research Hub will overcome complex challenges to pave the way for new Australian technologies that can be used at medical points of care, ordinary workplaces and centres of activity, to test for tiny quantities of materials that are early signals of disease or signs of drug, animal health, food quality or environmental issues. These disruptive technologies will give Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms global competitive advantages.

Publications:

Alghalayini, A, Garcia, A, Berry, T & Cranfield, C 2019, 'The Use of Tethered Bilayer Lipid Membranes to Identify the Mechanisms of Antimicrobial Peptide Interactions with Lipid Bilayers', Antibiotics, vol. 8, no. 1, pp. 12-12.
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Hossain, KR, Turkewitz, DR, Holt, SA, Herson, L, Brown, LJ, Cornell, BA, Curmi, PMG & Valenzuela, SM 2019, 'A conserved GXXXG motif in the transmembrane domain of CLIC proteins is essential for their cholesterol-dependant membrane interaction', Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1863, no. 8, pp. 1243-1253.
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Zhou, Y, Chen, Y, He, H, Liao, J, Duong, HTT, Parviz, M & Jin, D 2019, 'A homogeneous DNA assay by recovering inhibited emission of rare earth ions-doped upconversion nanoparticles', Journal of Rare Earths, vol. 37, no. 1, pp. 11-18.
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Bray, K, Cheung, L, Hossain, KR, Aharonovich, I, Valenzuela, SM & Shimoni, O 2018, 'Versatile multicolor nanodiamond probes for intracellular imaging and targeted labeling', Journal of Materials Chemistry B, vol. 6, no. 19, pp. 3078-3084.
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Chen, Y, Duong, HTT, Wen, S, Mi, C, Zhou, Y, Shimoni, O, Valenzuela, SM & Jin, D 2018, 'Exonuclease III-Assisted Upconversion Resonance Energy Transfer in a Wash-Free Suspension DNA Assay', Analytical Chemistry, vol. 90, no. 1, pp. 663-668.
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Duong, HTT, Chen, Y, Tawfik, SA, Wen, S, Parviz, M, Shimoni, O & Jin, D 2018, 'Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles', RSC Advances, vol. 8, no. 9, pp. 4842-4849.
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He, H, Howard, CB, Chen, Y, Wen, S, Lin, G, Zhou, J, Thurecht, KJ & Jin, D 2018, 'Bispecific Antibody-Functionalized Upconversion Nanoprobe', Analytical Chemistry, vol. 90, no. 5, pp. 3024-3029.
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Kaur, A, Shimoni, O & Wallach, M 2018, 'Novel screening test for celiac disease using peptide functionalised gold nanoparticles', World Journal of Gastroenterology, vol. 24, no. 47, pp. 5379-5390.
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Lin, G, Baker, MAB, Hong, M & Jin, D 2018, 'The Quest for Optical Multiplexing in Bio-discoveries', Chem, vol. 4, no. 5, pp. 997-1021.
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Wang, F, Wen, S, He, H, Wang, B, Zhou, Z, Shimoni, O & Jin, D 2018, 'Microscopic inspection and tracking of single upconversion nanoparticles in living cells', Light: Science & Applications, vol. 7, no. 4, pp. 18007-18007.
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Shimoni, O & Valenzuela, SM 2017, 'Nanotechnology in Biology and Medicine' in Vo-Dinh, T (ed), Nanotechnology in Biology and Medicine: Methods, Devices, and Applications, Second Edition, CRC Press, USA, pp. 47-59.
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Berhane, AM, Jeong, K, Bodrog, Z, Fiedler, S, Schröder, T, Triviño, NV, Palacios, T, Gali, A, Toth, M, Englund, D & Aharonovich, I 2017, 'Bright Room‐Temperature Single‐Photon Emission from Defects in Gallium Nitride', Advanced Materials, vol. 29, no. 12, pp. 1605092-1605092.
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Kaur, A, Shimoni, O & Wallach, M 2017, 'Celiac disease: from etiological factors to evolving diagnostic approaches', Journal of Gastroenterology, vol. 52, no. 9, pp. 1001-1012.
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Liu, Y, Lu, Y, Yang, X, Zheng, X, Wen, S, Wang, F, Vidal, X, Zhao, J, Liu, D, Zhou, Z, Ma, C, Zhou, J, Piper, JA, Xi, P & Jin, D 2017, 'Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy', Nature, vol. 543, no. 7644, pp. 229-233.
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Ma, C, Xu, X, Wang, F, Zhou, Z, Liu, D, Zhao, J, Guan, M, Lang, CI & Jin, D 2017, 'Optimal Sensitizer Concentration in Single Upconversion Nanocrystals', Nano Letters, vol. 17, no. 5, pp. 2858-2864.
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Schell, AW, Takashima, H, Tran, TT, Aharonovich, I & Takeuchi, S 2017, 'Coupling Quantum Emitters in 2D Materials with Tapered Fibers', ACS Photonics, vol. 4, no. 4, pp. 761-767.
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Tran, TT, Wang, D, Xu, Z-Q, Yang, A, Toth, M, Odom, TW & Aharonovich, I 2017, 'Deterministic Coupling of Quantum Emitters in 2D Materials to Plasmonic Nanocavity Arrays', Nano Letters, vol. 17, no. 4, pp. 2634-2639.
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Wu, R, Zhou, J, Lei, L, Zhang, S, Xiao, Z, Zhang, J & Xu, S 2017, 'α-NaYF4:Yb3+-Tm3+@CaF2 nanocrystals for NIR-to-NIR temperature sensing', Chemical Physics Letters, vol. 667, pp. 206-210.
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Aharonovich, I, Englund, D & Toth, M 2016, 'Solid-state single-photon emitters', Nature Photonics, vol. 10, no. 10, pp. 631-641.
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Choi, S, Tran, TT, Elbadawi, C, Lobo, C, Wang, X, Juodkazis, S, Seniutinas, G, Toth, M & Aharonovich, I 2016, 'Engineering and Localization of Quantum Emitters in Large Hexagonal Boron Nitride Layers', ACS APPLIED MATERIALS & INTERFACES, vol. 8, no. 43, pp. 29642-29648.
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Kianinia, M, Tawfik, SA, Regan, B, Tran, TT, Ford, MJ, Aharonovich, I & Toth, M 2016, 'Robust Solid State Quantum System Operating at 800 K', ACS Photonics, vol. 4, no. 4, pp. 768-773.
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Ma, C, Xu, X, Wang, F, Zhou, Z, Wen, S, Liu, D, Fang, J, Lang, CI & Jin, D 2016, 'Probing the Interior Crystal Quality in the Development of More Efficient and Smaller Upconversion Nanoparticles', The Journal of Physical Chemistry Letters, vol. 7, no. 16, pp. 3252-3258.
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FOR Codes: Medical Biotechnology Diagnostics (incl. Biosensors), Biomedical Instrumentation, Diagnostic Methods, Scientific Instruments, Veterinary Diagnostics, Human diagnostics, Instrumentation

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.