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Biomagnification of BMAA in the environment: development of new detection tools, determination of exposure routes and neurotoxic mechanisms.

Funding: 2016: $12,000
2017: $11,000
2018: $10,000
2019: $15,000
2020: $10,000

Project Member(s): Rodgers, K.

Funding or Partner Organisation: Macquarie University
Australian Research Council (ARC Discovery Projects)
Australian Research Council (ARC Discovery Projects)

Start year: 2016

Summary: Biomagnification of the biotoxin BMAA in the environment. Using unique models and technics, the project aims to demonstrate that long-term exposure to the blue green algae toxin β-N-methylamino-l-alanine (BMAA) leads to uptake, accumulation and toxicity within the central nervous system. The risks for heath, mechanisms of contamination and toxicity of BMAA are very poorly understood. Algal blooms cost the Australian community more than $250 million each year and represent a major health issue for human and fauna. This project aims to be the first to fully characterise BMAA mechanisms of contamination and neurotoxicity and to highlight the major environmental risk of exposure of human to BMAA. It also aims to develop new and unique detection and quantification tools for BMAA.

Publications:

Violi, JP, Facey, JA, Mitrovic, SM, Colville, A & Rodgers, KJ 2019, 'Production of β-methylamino-L-alanine (BMAA) and Its Isomers by Freshwater Diatoms', Toxins, vol. 11, no. 9, pp. 512-512.
View/Download from: Publisher's site

FOR Codes: Cell Neurochemistry, Environmental Science and Management not elsewhere classified, Freshwater Ecology, Urban and Industrial Water Management, Natural Hazards in Fresh, Ground and Surface Water Environments, Fresh, Ground and Surface Water Flora, Fauna and Biodiversity, Freshwater ecology , Environmental management not elsewhere classified, Fresh, ground and surface water systems and management, Natural hazards, Terrestrial systems and management