Fine-scale resolution of genomes in natural microbial communities

Funding: 2018: $170,000
2019: $156,750
2020: $139,608

Project Member(s): Darling, A.

Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)
Australian Research Council (ARC Discovery Projects)

Start year: 2018

Summary: Fine-scale resolution of genomes in natural microbial communities. This project aims to develop advanced molecular and statistical techniques to precisely resolve the genomes of microbes in the environment. Microbes inhabit every niche on the planet and are fundamental to human and animal health, agriculture, and the environment. The proposed technology will advance our understanding of environmental microbes, leading to advances in areas like climate science and biosecurity where microbes play a key role. It will also support the development of billion dollar industries focused on the use of beneficial microbes in agriculture, plant, animal, and human health.

Publications:

DeMaere, MZ & Darling, AE 2019, 'bin3C: exploiting Hi-C sequencing data to accurately resolve metagenome-assembled genomes', Genome Biology, vol. 20, no. 1, pp. 46-46.
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Fritz, A, Hofmann, P, Majda, S, Dahms, E, Dröge, J, Fiedler, J, Lesker, TR, Belmann, P, DeMaere, MZ, Darling, AE, Sczyrba, A, Bremges, A & McHardy, AC 2019, 'CAMISIM: simulating metagenomes and microbial communities', Microbiome, vol. 7, no. 1.
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DeMaere, MZ & Darling, AE 2018, 'bin3C : Exploiting Hi-C sequencing data to accurately resolve metagenome-assembled genomes (MAGs)', Genome Biology, vol. 20.
View/Download from: Publisher's site

FOR Codes: Population, Ecological and Evolutionary Genetics, Bioinformatics, Microbial Ecology, Expanding Knowledge in the Biological Sciences, Ecosystem Assessment and Management of Marine Environments, Genetics not elsewhere classified, Bioinformatics and computational biology, Assessment and management of terrestrial ecosystems

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.