Targeting leukaemia specific regulatory elements for the treatment of intermediate and high risk patients

Project Member(s): Beck, D.

Funding or Partner Organisation: Gilead Sciences Pty Ltd (Gilead Sciences International Research Scholars Program Hematology / Oncology)
Gilead Sciences Pty Ltd (Gilead Sciences International Research Scholars Program Hematology / Oncology)

Start year: 2017

Publications:

Subramanian, S, Thoms, JAI, Huang, Y, Cornejo-Páramo, P, Koch, FC, Jacquelin, S, Shen, S, Song, E, Joshi, S, Brownlee, C, Woll, PS, Chacon-Fajardo, D, Beck, D, Curtis, DJ, Yehson, K, Antonenas, V, O'Brien, T, Trickett, A, Powell, JA, Lewis, ID, Pitson, SM, Gandhi, MK, Lane, SW, Vafaee, F, Wong, ES, Göttgens, B, Alinejad-Rokny, H, Wong, JWH & Pimanda, JE 2023, 'Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs', Blood, vol. 142, no. 17, pp. 1448-1462.
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Chandrakanthan, V, Rorimpandey, P, Zanini, F, Chacon, D, Olivier, J, Joshi, S, Kang, YC, Knezevic, K, Huang, Y, Qiao, Q, Oliver, RA, Unnikrishnan, A, Carter, DR, Lee, B, Brownlee, C, Power, C, Brink, R, Mendez-Ferrer, S, Enikolopov, G, Walsh, W, Göttgens, B, Taoudi, S, Beck, D & Pimanda, JE 2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, vol. 24, no. 8, pp. 1211-1225.
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Thoms, J, Truong, P, Subramanian, S, Knezevic, K, Harvey, G, Huang, Y, Seneviratne, J, Carter, D, Joshi, S, Skhinas, J, Chacon, D, Shah, A, de Jong, I, Beck, D, Göttgens, B, Larsson, J, Wong, J, Zanini, F & Pimanda, J 2021, '3034 – DISRUPTION OF A GATA2, TAL1, ERG REGULATORY CIRCUIT PROMOTES ERYTHROID TRANSITION IN HEALTHY AND LEUKEMIC STEM CELLS', Experimental Hematology, vol. 100, pp. S59-S59.
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Yeola, A, Subramanian, S, Oliver, RA, Lucas, CA, Thoms, JAI, Yan, F, Olivier, J, Chacon, D, Tursky, ML, Srivastava, P, Potas, JR, Hung, T, Power, C, Hardy, P, Ma, DD, Kilian, KA, McCarroll, J, Kavallaris, M, Hesson, LB, Beck, D, Curtis, DJ, Wong, JWH, Hardeman, EC, Walsh, WR, Mobbs, R, Chandrakanthan, V & Pimanda, JE 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, no. 3, pp. 1-12.
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Thoms, J, Truong, P, Subramanian, S, Knezevic, K, Harvey, G, Huang, Y, Seneviratne, J, Carter, D, Joshi, S, Skhinas, J, Chacon, D, Shah, A, de Jong, I, Beck, D, Gottgens, B, Larsson, J, Wong, J, Zanini, F & Pimanda, J 1970, 'DISRUPTION OF A GATA2, TAL1, ERG REGULATORY CIRCUIT PROMOTES ERYTHROID TRANSITION IN HEALTHY AND LEUKEMIC STEM CELLS', EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S59-S59.

Carmichael, CL, Wang, J, Nguyen, T, Kolawole, O, Benyoucef, A, De Mazière, C, Milne, AR, Samuel, S, Gillinder, K, Hediyeh-zadeh, S, Vo, ANQ, Huang, Y, Knezevic, K, McInnes, WRL, Shields, BJ, Mitchell, H, Ritchie, ME, Lammens, T, Lintermans, B, Van Vlierberghe, P, Wong, NC, Haigh, K, Thoms, JAI, Toulmin, E, Curtis, DJ, Oxley, EP, Dickins, RA, Beck, D, Perkins, A, McCormack, MP, Davis, MJ, Berx, G, Zuber, J, Pimanda, JE, Kile, BT, Goossens, S & Haigh, JJ 2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1', Blood, vol. 136, no. 8, pp. 957-973.
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Yeola, A, Subramanian, S, Oliver, RA, Lucas, CA, Thoms, JAI, Yan, F, Olivier, J, Chacon, D, Tursky, ML, Hung, T, Power, C, Hardy, P, Ma, DD, McCarroll, J, Kavallaris, M, Hesson, LB, Beck, D, Curtis, DJ, Wong, JWH, Hardeman, EC, Walsh, WR, Mobbs, R, Chandrakanthan, V & Pimanda, JE 2020, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Cold Spring Harbor Laboratory.
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Chacon, D, Braytee, A, Huang, Y, Thoms, J, Subramanian, S, Sauerland, MC, Bohlander, SK, Braess, J, Wörmann, BJ, Berdel, WE, Hiddemann, W, Gabrys, B, Metzeler, KH, Herold, T, Pimanda, J & Beck, D 2019, 'Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification', American Society of Hematology, pp. 1397-1397.
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Beck, D, Thoms, JAI, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, BJ, Schwarzer, A, Klusmann, J-H, Berdel, WE, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, SK, To, LB, Scott, HS, Lewis, ID, D'Andrea, RJ, Wong, JWH & Pimanda, JE 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, vol. 32, no. 2, pp. 263-272.
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Jing, D, Huang, Y, Liu, X, Sia, KCS, Zhang, JC, Tai, X, Wang, M, Toscan, CE, McCalmont, H, Evans, K, Mayoh, C, Poulos, RC, Span, M, Mi, J, Zhang, C, Wong, JWH, Beck, D, Pimanda, JE & Lock, RB 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, vol. 34, no. 6, pp. 906-921.e8.
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Liu, K, Beck, D, Thoms, JAI, Liu, L, Zhao, W, Pimanda, JE & Zhou, X 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics, vol. 33, no. 17, pp. 2622-2630.
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FOR Codes: Haematological Tumours, Blood Disorders, Clinical health

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.