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Targeting leukaemia specific regulatory elements for the treatment of intermediate and high risk patients

Project Member(s): Beck, D.

Funding or Partner Organisation: Gilead Sciences Pty Ltd (Gilead Sciences International Research Scholars Program Hematology / Oncology)
Gilead Sciences Pty Ltd (Gilead Sciences International Research Scholars Program Hematology / Oncology)

Start year: 2017


Carmichael, CL, Wang, J, Nguyen, T, Kolawole, O, Benyoucef, A, De Mazière, C, Milne, A, Samuel, S, Gillinder, KR, Hediyeh-Zadeh, S, Vo, ANQ, Huang, Y, Knezevic, K, McInnes, WRL, Shields, BJ, Mitchell, H, Ritchie, ME, Lammens, T, Lintermans, B, Van Vlierberghe, P, Wong, N, Haigh, K, Thoms, JAI, Toulmin, E, Curtis, DJ, Oxley, EP, Dickins, RA, Beck, D, Perkins, AC, McCormack, MP, Davis, MJ, Berx, G, Zuber, J, Pimanda, JE, Kile, BT, Goossens, S & Haigh, JJ 2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.', Blood.
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Beck, D, Thoms, JAI, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, BJ, Schwarzer, A, Klusmann, J-H, Berdel, WE, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, SK, To, LB, Scott, HS, Lewis, ID, D'Andrea, RJ, Wong, JWH & Pimanda, JE 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.', Leukemia, vol. 32, no. 2, pp. 263-272.
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Jing, D, Huang, Y, Liu, X, Sia, KCS, Zhang, JC, Tai, X, Wang, M, Toscan, CE, McCalmont, H, Evans, K, Mayoh, C, Poulos, RC, Span, M, Mi, J, Zhang, C, Wong, JWH, Beck, D, Pimanda, JE & Lock, RB 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', CANCER CELL, vol. 34, no. 6, pp. 906-+.
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Liu, K, Beck, D, Thoms, JAI, Liu, L, Zhao, W, Pimanda, JE & Zhou, X 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics, vol. 33, no. 17, pp. 2622-2630.
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FOR Codes: Haematological Tumours, Blood Disorders