Leverageing artifical intelligence and genome editing for treatment of AML

Project Member(s): Beck, D.

Funding or Partner Organisation: Anthony Rothe Memorial Trust (Anthony Rothe Memorial Trust Project Grants)
Anthony Rothe Memorial Trust (Anthony Rothe Memorial Trust Project Grants)

Start year: 2018

Publications:

Subramanian, S, Thoms, JAI, Huang, Y, Cornejo-Páramo, P, Koch, FC, Jacquelin, S, Shen, S, Song, E, Joshi, S, Brownlee, C, Woll, PS, Chacon-Fajardo, D, Beck, D, Curtis, DJ, Yehson, K, Antonenas, V, O'Brien, T, Trickett, A, Powell, JA, Lewis, ID, Pitson, SM, Gandhi, MK, Lane, SW, Vafaee, F, Wong, ES, Göttgens, B, Alinejad-Rokny, H, Wong, JWH & Pimanda, JE 2023, 'Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs', Blood, vol. 142, no. 17, pp. 1448-1462.
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Chandrakanthan, V, Rorimpandey, P, Zanini, F, Chacon, D, Olivier, J, Joshi, S, Kang, YC, Knezevic, K, Huang, Y, Qiao, Q, Oliver, RA, Unnikrishnan, A, Carter, DR, Lee, B, Brownlee, C, Power, C, Brink, R, Mendez-Ferrer, S, Enikolopov, G, Walsh, W, Göttgens, B, Taoudi, S, Beck, D & Pimanda, JE 2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, vol. 24, no. 8, pp. 1211-1225.
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Thoms, J, Truong, P, Subramanian, S, Knezevic, K, Harvey, G, Huang, Y, Seneviratne, J, Carter, D, Joshi, S, Skhinas, J, Chacon, D, Shah, A, de Jong, I, Beck, D, Göttgens, B, Larsson, J, Wong, J, Zanini, F & Pimanda, J 2021, '3034 – DISRUPTION OF A GATA2, TAL1, ERG REGULATORY CIRCUIT PROMOTES ERYTHROID TRANSITION IN HEALTHY AND LEUKEMIC STEM CELLS', Experimental Hematology, vol. 100, pp. S59-S59.
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Yeola, A, Subramanian, S, Oliver, RA, Lucas, CA, Thoms, JAI, Yan, F, Olivier, J, Chacon, D, Tursky, ML, Srivastava, P, Potas, JR, Hung, T, Power, C, Hardy, P, Ma, DD, Kilian, KA, McCarroll, J, Kavallaris, M, Hesson, LB, Beck, D, Curtis, DJ, Wong, JWH, Hardeman, EC, Walsh, WR, Mobbs, R, Chandrakanthan, V & Pimanda, JE 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, no. 3, pp. 1-12.
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Thoms, J, Truong, P, Subramanian, S, Knezevic, K, Harvey, G, Huang, Y, Seneviratne, J, Carter, D, Joshi, S, Skhinas, J, Chacon, D, Shah, A, de Jong, I, Beck, D, Gottgens, B, Larsson, J, Wong, J, Zanini, F & Pimanda, J 1970, 'DISRUPTION OF A GATA2, TAL1, ERG REGULATORY CIRCUIT PROMOTES ERYTHROID TRANSITION IN HEALTHY AND LEUKEMIC STEM CELLS', EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S59-S59.

Carmichael, CL, Wang, J, Nguyen, T, Kolawole, O, Benyoucef, A, De Mazière, C, Milne, AR, Samuel, S, Gillinder, K, Hediyeh-zadeh, S, Vo, ANQ, Huang, Y, Knezevic, K, McInnes, WRL, Shields, BJ, Mitchell, H, Ritchie, ME, Lammens, T, Lintermans, B, Van Vlierberghe, P, Wong, NC, Haigh, K, Thoms, JAI, Toulmin, E, Curtis, DJ, Oxley, EP, Dickins, RA, Beck, D, Perkins, A, McCormack, MP, Davis, MJ, Berx, G, Zuber, J, Pimanda, JE, Kile, BT, Goossens, S & Haigh, JJ 2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1', Blood, vol. 136, no. 8, pp. 957-973.
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Yeola, A, Subramanian, S, Oliver, RA, Lucas, CA, Thoms, JAI, Yan, F, Olivier, J, Chacon, D, Tursky, ML, Hung, T, Power, C, Hardy, P, Ma, DD, McCarroll, J, Kavallaris, M, Hesson, LB, Beck, D, Curtis, DJ, Wong, JWH, Hardeman, EC, Walsh, WR, Mobbs, R, Chandrakanthan, V & Pimanda, JE 2020, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Cold Spring Harbor Laboratory.
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Chacon, D, Braytee, A, Huang, Y, Thoms, J, Subramanian, S, Sauerland, MC, Bohlander, SK, Braess, J, Wörmann, BJ, Berdel, WE, Hiddemann, W, Gabrys, B, Metzeler, KH, Herold, T, Pimanda, J & Beck, D 2019, 'Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification', American Society of Hematology, pp. 1397-1397.
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Jing, D, Huang, Y, Liu, X, Sia, KCS, Zhang, JC, Tai, X, Wang, M, Toscan, CE, McCalmont, H, Evans, K, Mayoh, C, Poulos, RC, Span, M, Mi, J, Zhang, C, Wong, JWH, Beck, D, Pimanda, JE & Lock, RB 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, vol. 34, no. 6, pp. 906-921.e8.
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FOR Codes: Haematological Tumours, Blood Disorders, Clinical health