Complete blood fractionation using a low-cost microfluidic system

Funding: 2017: $97,812
2018: $90,000
2019: $99,000
2017: $94,603
2018: $90,000
2019: $99,000

Project Member(s): Ebrahimi Warkiani, M.

Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)
Australian Research Council (ARC Discovery Projects)

Start year: 2017

Summary: Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The knowledge and models developed in this project should help design and develop a microfluidic device for efficient fractionation of complex fluids into valuable components.

Publications:

Condina, MR, Dilmetz, BA, Razavi Bazaz, S, Meneses, J, Ebrahimi Warkiani, M & Hoffmann, P 2019, 'Rapid separation and identification of beer spoilage bacteria by inertial microfluidics and MALDI-TOF mass spectrometry', Lab on a Chip, vol. 19, no. 11, pp. 1961-1970.
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Moloudi, R, Oh, S, Yang, C, Teo, KL, Lam, AT, Ebrahimi Warkiani, M & Win Naing, M 2019, 'Scaled‐Up Inertial Microfluidics: Retention System for Microcarrier‐Based Suspension Cultures', Biotechnology Journal, vol. 14, no. 5, pp. 1800674-1800674.
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Rafeie, M, Hosseinzadeh, S, Huang, J, Mihandoust, A, Warkiani, ME & Taylor, RA 2019, 'New insights into the physics of inertial microfluidics in curved microchannels. II. Adding an additive rule to understand complex cross-sections', Biomicrofluidics, vol. 13, no. 3, pp. 034118-034118.
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Rafeie, M, Hosseinzadeh, S, Taylor, RA & Warkiani, ME 2019, 'New insights into the physics of inertial microfluidics in curved microchannels. I. Relaxing the fixed inflection point assumption', Biomicrofluidics, vol. 13, no. 3, pp. 034117-034117.
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Raoufi, MA, Mashhadian, A, Niazmand, H, Asadnia, M, Razmjou, A & Warkiani, ME 2019, 'Experimental and numerical study of elasto-inertial focusing in straight channels', Biomicrofluidics, vol. 13, no. 3, pp. 034103-034103.
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Razavi Bazaz, S, Kashaninejad, N, Azadi, S, Patel, K, Asadnia, M, Jin, D & Ebrahimi Warkiani, M 2019, 'Rapid Softlithography Using 3D‐Printed Molds', Advanced Materials Technologies, vol. 4, no. 10, pp. 1900425-1900425.
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Hassanzadeh-Barforoushi, A, Law, AMK, Hejri, A, Asadnia, M, Ormandy, CJ, Gallego-Ortega, D & Ebrahimi Warkiani, M 2018, 'Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment', Lab on a Chip, vol. 18, no. 15, pp. 2156-2166.
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Kulasinghe, A, Wu, H, Punyadeera, C & Warkiani, ME 2018, 'The Use of Microfluidic Technology for Cancer Applications and Liquid Biopsy', Micromachines, vol. 9, no. 8, pp. 397-397.
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Moloudi, R, Oh, S, Yang, C, Ebrahimi Warkiani, M & Naing, MW 2018, 'Inertial particle focusing dynamics in a trapezoidal straight microchannel: application to particle filtration', Microfluidics and Nanofluidics, vol. 22, no. 3.
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Stefen, H, Hassanzadeh-Barforoushi, A, Brettle, M, Fok, S, Suchowerska, AK, Tedla, N, Barber, T, Warkiani, ME & Fath, T 2018, 'A Novel Microfluidic Device-Based Neurite Outgrowth Inhibition Assay Reveals the Neurite Outgrowth-Promoting Activity of Tropomyosin Tpm3.1 in Hippocampal Neurons', Cellular and Molecular Neurobiology, vol. 38, no. 8, pp. 1557-1563.
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Asadnia, M, Khorasani, AM & Warkiani, ME 2017, 'An Accurate PSO-GA Based Neural Network to Model Growth of Carbon Nanotubes', Journal of Nanomaterials, vol. 2017, pp. 1-6.
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FOR Codes: Cancer Cell Biology, Biomedical Engineering, Expanding Knowledge in Engineering

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.