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Luminescent Nanoparticles for Controlled Localized Release of Immunomodulatory Agents

Project Member(s): Xu, X., McClements, L.

Funding or Partner Organisation: Juvenile Diabetes Foundation International (JDRF Innovation Grant)
Juvenile Diabetes Foundation International (JDRF Innovation Grant)

Start year: 2020

Summary: The critical question to be addressed is how to maintain long-term the function of encapsulated insulin-producing cells placed in a scaffold and implanted subcutaneously in diabetic allografted recipients. Currently, in our hands, it is possible to achieve reasonable function for up to 90 days, without administering immunomodulatory molecules to the recipient. However, thereafter blood glucose levels start to increase as the desirable host reaction to the scaffolds starts to involve the microcapsules and inhibit the inflow of nutrients and exit of insulin. The proposed new approach is to load immuno-modulatory molecules to core-shell luminescent nanoparticles inserted in alginate microcapsules, that when exposed to infrared light will result in start releasing of the molecules at low power and stop releasing at high power, thereby inhibiting the host reaction to the microcapsules. This should maintain the functional capacity of the encapsulated insulin-producing cells. Its use would be restricted to subcutaneous (s/c) transplants where light waves could reach the implant.

FOR Codes: Diabetes, Nanotechnology, Medical Biochemistry and Metabolomics