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Cell free microRNA: potential biomarkers for the early detection of lung cancer

Project Member(s): Hansbro, P.

Funding or Partner Organisation: Thoracic Society of Australia and New Zealand
Thoracic Society of Australia and New Zealand

Start year: 2020

Summary: Lung cancer (LC) is the leading cause of cancer associated death globally with >50% of these being adenocarcinomas. The high mortality rates associated with LC are mainly due to the lack of effective early diagnostics. Thus, it is crucial to develop effective early diagnostics for LC. The differential presence of miRNAs has been reported in several studies of LC in both experimental mouse models and human tumours16. miRNAs control cellular and pathological processes such as proliferation, differentiation, apoptosis, immunity, metabolism and stem-cell maintenance that are relevant to LC. We will profile cf-miRNAs in serum in tobaccocarcinogen/ cigarette smoke (CS)-induced experimental LC using small RNA-seq and identify those that are candidate biomarkers.

FOR Codes: Cardiovascular medicine and haematology, Respiratory System and Diseases (incl. Asthma), Cardiorespiratory Medicine and Haematology, Clinical health