Skip to main content

Prediction of fracture by clinico-genetic profiling

Project Member(s): Nguyen, T.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC Investigator Grants)
National Health & Medical Research Council (NHMRC Investigator Grants)

Start year: 2021

Summary: Longitudinal bone loss is a direct cause of osteoporosis and a major risk factor for fragility fracture. Despite its clinical importance and genetic link, bone loss is an understudied trait. Although several genetic variants associated with bone mineral density have been found, no genes for bone loss have been identified.

Publications:

De Dios, K, Ngoc, H, Tran, TS, Center, JR & Nguyen, TV 2023, 'Contribution of fat mass and obesity-associated (FTO) gene to osteoporosis phenotypes', WILEY, pp. 256-256.

Agarwal, A, Leslie, WD, Nguyen, TV, Morin, SN, Lix, LM & Eisman, JA 2022, 'Performance of the Garvan Fracture Risk Calculator in Individuals with Diabetes: A Registry-Based Cohort Study', Calcified Tissue International, vol. 110, no. 6, pp. 658-665.
View/Download from: Publisher's site

Agarwal, A, Leslie, WD, Nguyen, TV, Morin, SN, Lix, LM & Eisman, JA 2022, 'Predictive performance of the Garvan Fracture Risk Calculator: a registry-based cohort study', Osteoporosis International, vol. 33, no. 3, pp. 541-548.
View/Download from: Publisher's site

Nguyen, TV 2022, 'Personalised assessment of fracture risk: Which tool to use?', Australian Journal of General Practice, vol. 51, no. 3, pp. 189-190.
View/Download from: Publisher's site

Ho-Le, TP, Tran, TS, Bliuc, D, Pham, HM, Frost, SA, Center, JR, Eisman, JA & Nguyen, TV 2021, 'Epidemiological transition to mortality and refracture following an initial fracture', eLife, vol. 10, pp. 1-15.
View/Download from: Publisher's site

Iuliano, S, Poon, S, Robbins, J, Bui, M, Wang, X, De Groot, L, Van Loan, M, Zadeh, AG, Nguyen, T & Seeman, E 2021, 'Effect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial', BMJ, vol. 375, pp. n2364-n2364.
View/Download from: Publisher's site

Nguyen, TV 2021, 'Personalized fracture risk assessment: where are we at?', Expert Review of Endocrinology & Metabolism, vol. 16, no. 4, pp. 191-200.
View/Download from: Publisher's site

Ni Chroinin, D, Wilson, C, Marov, L, Kelly, A, Gaudin, J, El Haddad, C, Center, J, Eisman, JA, Nguyen, TV, Hassett, G & Frost, SA 2021, 'The slippery slope of breaking a bone: Recent prior fracture common amongst hip fracture patients (a retrospective observational study)', WILEY, pp. 70-71.

Ho-Le, TP & Nguyen, TV 2020, 'Hip Fracture and Mortality: A Loss of Life Expectancy Interpretation', Journal of Bone and Mineral Research, vol. 36, no. 12, pp. 2457-2458.
View/Download from: Publisher's site

Nguyen, TV 2020, 'Common methodological issues and suggested solutions in bone research', Osteoporosis and Sarcopenia, vol. 6, no. 4, pp. 161-167.
View/Download from: Publisher's site

Nguyen, TV & Eisman, JA 2020, 'Post‐GWAS Polygenic Risk Score: Utility and Challenges', JBMR Plus, vol. 4, no. 11, p. e10411.
View/Download from: Publisher's site

FOR Codes: Clinical sciences, Skeletal System and Disorders (incl. Arthritis), Clinical health