Multiparameter analysis of exosomes for non-invasive early detection of pancreatic cancer using a point-of-care nanoplasmonic sensor

Project Member(s): Zhu, Y.

Funding or Partner Organisation: Pankind, The Australian Pancreatic Cancer Foundation (prev AVNER Pancreatic Cancer Foundation) (Collaboration Grant)
Pankind, The Australian Pancreatic Cancer Foundation (prev AVNER Pancreatic Cancer Foundation) (Collaboration Grant)

Start year: 2020

Summary: Early detection of PC is very important enabling patients to access early treatment options which leads to better outcomes. Therefore, a screening method for early detection of PC that can be used for regular monitoring is urgently needed. The project aims to develop a blood test to detect PC in early stages. The target is exosomes, a fragment released by cancer cells, which have been shown as promising and more accurate biomarkers (i.e. biological clues) for PC diagnosis. The project will develop an integrated and small device for rapid and sensitive exosomes analysis for clinical use. The project will define a set of biomarkers that can differentiate cancer and non-cancer subject from human cells and plasma carrying early signs of human PC.

Publications:

Zhand, S, Xiao, K, Razavi Bazaz, S, Zhu, Y, Bordhan, P, Jin, D & Warkiani, ME 2021, 'Improving capture efficiency of human cancer cell derived exosomes with nanostructured metal organic framework functionalized beads', Applied Materials Today, vol. 23, pp. 100994-100994.
View/Download from: Publisher's site

FOR Codes: Cancer Diagnosis, Nanotechnology, Medical Devices, Expanding Knowledge in the Medical and Health Sciences, Expanding Knowledge in Technology, EXPANDING KNOWLEDGE

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.