Deciphering the molecular mechanisms of parasite-host interactions
Funding: 2021: $202,229
Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)
Australian Research Council (ARC Discovery Projects)
Start year: 2021
Summary: Helminth parasites have little similarity to the model organism (C. elegans) in which worm miRNA activity has been broadly characterised. Understanding the molecular mechanisms that helminths use to regulate parasite-host interactions is crucial to our understanding of the fundamental biology of these organisms and will be of enormous benefit to the development of novel strategies for infection control. A comprehensive characterisation and functional analysis of miRNAs in F. hepatica will create a new mechanistic framework for the regulation of host immune responses by parasite-secreted miRNAs and reveal the molecular biological pathways that are unique to parasitism and parasitic disease.
FOR Codes: Expanding Knowledge, Agricultural And Veterinary Sciences, Veterinary parasitology