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Deciphering the molecular mechanisms of parasite-host interactions

Funding: 2021: $202,229
2022: $206,273
2023: $159,447

Project Member(s): Donnelly, S.

Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)
Australian Research Council (ARC Discovery Projects)

Start year: 2021

Summary: Helminth parasites have little similarity to the model organism (C. elegans) in which worm miRNA activity has been broadly characterised. Understanding the molecular mechanisms that helminths use to regulate parasite-host interactions is crucial to our understanding of the fundamental biology of these organisms and will be of enormous benefit to the development of novel strategies for infection control. A comprehensive characterisation and functional analysis of miRNAs in F. hepatica will create a new mechanistic framework for the regulation of host immune responses by parasite-secreted miRNAs and reveal the molecular biological pathways that are unique to parasitism and parasitic disease.

FOR Codes: Expanding Knowledge, Agricultural And Veterinary Sciences, Veterinary parasitology