Novel ‘Mechano-medicine’ combats deadly sticky blood clots in diabetes

Project Member(s): Su, Q.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC - Ideas Grants)
National Health & Medical Research Council (NHMRC - Ideas Grants)

Start year: 2021

Summary: This project aims to elucidate a novel biomechanical mechanism that associates with mechanical force generated by dynamic blood flow and leads to enhanced blood clotting in diabetes. The outcome may likely explain the reduced efficacy of current anti-clotting drugs (i.e. Aspirin, Plavix® or Brilinta®) in individuals with diabetes, which does not take the ‘force effect’ into account. Moreover, it will provide an innovative therapeutic strategy to reduce the sticky blood clots of diabetes.

Publications:

Li, Y, Xue, B, Zhang, M, Zhang, L, Hou, Y, Qin, Y, Long, H, Su, QP, Wang, Y, Guan, X, Jin, Y, Cao, Y, Li, G & Sun, Y 2021, 'Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency', Genome Biology, vol. 22, no. 1, pp. 1-29.
View/Download from: Publisher's site

Miao, MZ, Collins, JA, Bahnson, EM, Diekman, BO, Su, PQ, Chubinskaya, S & Loeser, RF 2021, 'Temporospatial production of reactive oxygen species in articular chondrocytes is induced by the endocytosis of fibronectin fragments, alpha 5 beta 1 integrin and NADPH oxidase 2', Elsevier BV, pp. S114-S115.
View/Download from: Publisher's site

FOR Codes: Cardiology (incl. Cardiovascular Diseases), Cardiorespiratory Medicine and Haematology not elsewhere classified, Biomedical Engineering, Diabetes, Cardiovascular medicine and haematology not elsewhere classified, Clinical health