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Defining the impact of chronic lung disease on COVID-19 and developing effective therapies

Project Member(s): Hansbro, N., Hansbro, P., Faiz, A., Idrees, S., Johansen, M., Saunders, B.

Funding or Partner Organisation: National Health & Medical Research Council (NHMRC - Ideas Grants)
National Health & Medical Research Council (NHMRC - Ideas Grants)

Start year: 2022

Summary: Patients with chronic illnesses, including chronic obstructive pulmonary disease (COPD), tuberculosis (TB) and cardiovascular disease, have increased predisposition to severe COVID-19 disease. We shall undertake an integrated series of experiments to understand how chronic lung disease increases susceptibility and severity of COVID-19, and how CoV2 infection exacerbates TB and COPD.

Publications:

Johansen, MD, Mahbub, RM, Idrees, S, Nguyen, DH, Miemczyk, S, Pathinayake, P, Nichol, K, Hansbro, NG, Gearing, LJ, Hertzog, PJ, Gallego-Ortega, D, Britton, WJ, Saunders, BM, Wark, PA, Faiz, A & Hansbro, PM 2022, 'Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 6, pp. 712-729.
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FOR Codes: Respiratory diseases , Prevention of human diseases and conditions