A vascularised lung-on-a-chip model for nanotoxicity testing

Project Member(s): Ebrahimi Warkiani, M.

Funding or Partner Organisation: Cancer Institute NSW (Cancer Institute NSW - Career Development Fellowships)
Cancer Institute NSW (Cancer Institute NSW - Career Development Fellowships)

Start year: 2022

Summary: The specific outcomes of the project will be: • An advanced 3D-lung-on-a-chip model incorporating bronchial organoids and flow of immune cells to physiologically recapitulate an in-vivo lung microenvironment. • A low-cost and reliable pre-clinical lung model that will enable clinicians and researchers to better understand the changes occurring in the lung microenvironment on exposure to NPs. • A paradigm shift in toxicity and drug screening. • Advancement of public health by enabling faster, low-cost testing of drug candidates for the ultimate safe and effective treatment of cancer, inflammatory, infectious, and autoimmune diseases.

FOR Codes: Health, Expanding Knowledge in the Biological Sciences, Microfluidics and nanofluidics, Cancer cell biology

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.