Skip to main content

Targeted delivery of Berberine engineered nanoparticles as a therapeutic intervention for influenza infection in chronic obstructive pulmonary disease.

Project Member(s): Dua, K., Adams, J., Hansbro, P., Paudel, K., Oliver, B.

Funding or Partner Organisation: Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) (Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise)
Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) (Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise)

Start year: 2021

Summary: This innovative pilot study will advance the current knowledge of berberine through advanced drug delivery to treat IAV infection in both healthy and COPD populations. It will also assist us in identifying the optimal concentration of Berberine-loaded nanoparticles that could be translated to the animal models furthering our understanding of the therapeutic effectiveness of Berberine. The findings from this study would lay the foundation for further research into IAV-mediated inflammation in COPD and other related respiratory diseases. This will allow us to apply for external funding applications in 2022 with national competitive (NHMRC), philanthropic organisations and industry.

Publications:

Haysom‐McDowell, A, Paudel, KR, Yeung, S, Kokkinis, S, El Sherkawi, T, Chellappan, DK, Adams, J, Dua, K & De Rubis, G 2025, 'Recent trends and therapeutic potential of phytoceutical‐based nanoparticle delivery systems in mitigating non‐small cell lung cancer', Molecular Oncology, vol. 19, no. 1, pp. 15-36.
View/Download from: Publisher's site

Bani Saeid, A, De Rubis, G, Williams, KA, Yeung, S, Chellappan, DK, Singh, SK, Gupta, G, Hansbro, PM, Shahbazi, M-A, Gulati, M, Kaur, IP, Santos, HA, Paudel, KR & Dua, K 2024, 'Revolutionizing lung health: Exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases', Chemico-Biological Interactions, vol. 395, pp. 111009-111009.
View/Download from: Publisher's site

Datsyuk, JK, De Rubis, G, Paudel, KR, Kokkinis, S, Oliver, BGG & Dua, K 2024, 'Cellular probing using phytoceuticals encapsulated advanced delivery systems in ameliorating lung diseases: Current trends and future prospects', International Immunopharmacology, vol. 141, pp. 112913-112913.
View/Download from: Publisher's site

De Rubis, G, Paudel, KR, Allam, VSRR, Malyla, V, Subramaniyan, V, Singh, SK, Panth, N, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2024, 'Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles', Pathology - Research and Practice, vol. 253, pp. 154971-154971.
View/Download from: Publisher's site

De Rubis, G, Paudel, KR, Corrie, L, Mehndiratta, S, Patel, VK, Kumbhar, PS, Manjappa, AS, Disouza, J, Patravale, V, Gupta, G, Manandhar, B, Rajput, R, Robinson, AK, Reyes, R-J, Chakraborty, A, Chellappan, DK, Singh, SK, Oliver, BGG, Hansbro, PM & Dua, K 2024, 'Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 5, pp. 2793-2833.
View/Download from: Publisher's site

Jessamine, V, Mehndiratta, S, De Rubis, G, Paudel, KR, Shetty, S, Suares, D, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K 2024, 'The application of nanoparticles as advanced drug delivery systems in Attenuating COPD', Heliyon, vol. 10, no. 3, pp. e25393-e25393.
View/Download from: Publisher's site

Kokkinis, S, Singh, M, Paudel, KR, De Rubis, G, Bani Saeid, A, Jessamine, V, Datsyuk, J, Singh, SK, Vishwas, S, Adams, J, Hansbro, PM, Oliver, B, Gupta, G, Dureja, H & Dua, K 2024, 'Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges', Food Bioscience, vol. 58, pp. 103761-103761.
View/Download from: Publisher's site

Kulkarni, MP, Paudel, KR, Saeid, AB, De Rubis, G, Chellappan, DK, Singh, M, Singh, SK, Gupta, G, Shahbazi, M-A, Oliver, BGG, Amiji, MM, Santos, HA & Dua, K 2024, 'Interplay of nano-based delivery systems and protein signalling in ameliorating lung diseases', Journal of Drug Delivery Science and Technology, vol. 102, pp. 106432-106432.
View/Download from: Publisher's site

Wong, SL, Gan, JS, De Rubis, G, Paudel, KR, Yeung, S, Chellappan, DK, Keng, PS & Dua, K 2024, 'Innovative phytoceutical-based drug delivery in the management of pulmonary fibrosis: A roadmap towards inhaled therapeutics', Journal of Drug Delivery Science and Technology, vol. 99, pp. 105942-105942.
View/Download from: Publisher's site

Bani Saeid, A, Patel, VK, Mehndiratta, S, Rajput, R, Kundu, RK, Singh, SK, Chellappan, DK, Kokkinis, S, De Rubis, G, Collet, T, Paudel, KR, Hansbro, PM & Dua, K 2023, 'Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases', Food Bioscience, vol. 56, pp. 103205-103205.
View/Download from: Publisher's site

Chakraborty, A, Paudel, KR, Wang, C, De Rubis, G, Chellappan, DK, Hansbro, PM, Samuel, CS & Dua, K 2023, 'Anti-inflammatory and anti-fibrotic effects of berberine-loaded liquid crystalline nanoparticles.', EXCLI J, vol. 22, pp. 1104-1108.
View/Download from: Publisher's site

De Rubis, G, Paudel, KR, Liu, G, Agarwal, V, MacLoughlin, R, de Jesus Andreoli Pinto, T, Singh, SK, Adams, J, Nammi, S, Chellappan, DK, Oliver, BGG, Hansbro, PM & Dua, K 2023, 'Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells', Toxicology in Vitro, vol. 92, pp. 105660-105660.
View/Download from: Publisher's site

Malyla, V, De Rubis, G, Paudel, KR, Chellappan, DK, Hansbro, NG, Hansbro, PM & Dua, K 2023, 'Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 396, no. 12, pp. 3595-3603.
View/Download from: Publisher's site

Patel, VK, Vishwas, S, Kumar, R, De Rubis, G, Shukla, SD, Paudel, KR, Manandhar, B, Singh, TG, Chellappan, DK, Gulati, M, Kaur, IP, Allam, VSRR, Hansbro, PM, Oliver, BG, MacLoughlin, R, Singh, SK & Dua, K 2023, 'Tackling the cytokine storm using advanced drug delivery in allergic airway disease', Journal of Drug Delivery Science and Technology, vol. 82, pp. 104366-104366.
View/Download from: Publisher's site

De Rubis, G, Paudel, KR & Dua, K 2023, 'Modernizing traditional medicine: nanoparticle-based drug delivery systems to improve the delivery of phytoceuticals in managing chronic respiratory diseases'.

De Rubis, G, Paudel, KR, Liu, G, Hansbro, P, Adams, J, Oliver, B & Dua, K 2023, 'Berberine-loaded nanoparticles attenuate TGF-β-induced remodelling features in human bronchial epithelial cells'.

Paudel, KR, Manandhar, B, Singh, SK, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2023, 'Cytotoxic mechanisms of berberine-phytantriol liquid crystalline nanoparticles against non-small-cell lung cancer.', IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, pp. 516-519.
View/Download from: Publisher's site

Devkota, HP, Adhikari-Devkota, A, Paudel, KR, Panth, N, Gupta, G, Chellappan, DK, Hansbro, PM & Dua, K 2022, 'Phytochemicals and their Nanoformulations Targeted for Pulmonary Diseases' in Chellappan, DK, Pabreja, K & Faiyazuddin, M (eds), Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, Springer Singapore, Singapore, pp. 95-106.
View/Download from: Publisher's site

Chellappan, DK, Paudel, KR, Tan, NW, Cheong, KS, Khoo, SSQ, Seow, SM, Chellian, J, Candasamy, M, Patel, VK, Arora, P, Singh, PK, Singh, SK, Gupta, G, Oliver, BG, Hansbro, PM & Dua, K 2022, 'Targeting the mitochondria in chronic respiratory diseases', Mitochondrion, vol. 67, pp. 15-37.
View/Download from: Publisher's site

Paudel, KR, Mehta, M, Shukla, SD, Panth, N, Chellappan, DK, Dua, K & Hansbro, P 2022, 'Advancements in Nanotherapeutics Targeting Senescence in Chronic Obstructive Pulmonary Disease', Nanomedicine, vol. 17, no. 23, pp. 1757-1760.
View/Download from: Publisher's site

Paudel, KR, Mehta, M, Yin, GHS, Yen, LL, Malyla, V, Patel, VK, Panneerselvam, J, Madheswaran, T, MacLoughlin, R, Jha, NK, Gupta, PK, Singh, SK, Gupta, G, Kumar, P, Oliver, BG, Hansbro, PM, Chellappan, DK & Dua, K 2022, 'Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro', Environmental Science and Pollution Research, vol. 29, no. 31, pp. 46830-46847.
View/Download from: Publisher's site

Mehta, M, Malyla, V, Paudel, KR, Chellappan, DK, Hansbro, PM, Oliver, BG & Dua, K 2021, 'Berberine loaded liquid crystalline nanostructure inhibits cancer progression in adenocarcinomic human alveolar basal epithelial cells in vitro', Journal of Food Biochemistry, vol. 45, no. 11, p. e13954.
View/Download from: Publisher's site

Alnuqaydan, A, Almutary, A, Azam, M, Manandhar, B, Yin, G, Yen, L, Madheswaran, T, Paudel, K, Hansbro, P, Chellappan, D & Dua, K, 'Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro', Pharmaceutics, vol. 14, no. 6, pp. 1119-1119.
View/Download from: Publisher's site

Clarence, DD, Paudel, KR, Manandhar, B, Singh, SK, Devkota, HP, Panneerselvam, J, Gupta, V, Chitranshi, N, Verma, N, Saad, S, Gupta, G, Hansbro, PM, Oliver, BG, Madheswaran, T, Dua, K & Chellappan, DK, 'Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases', Nutrients, vol. 14, no. 18, pp. 3828-3828.
View/Download from: Publisher's site

Paudel, KR, Panth, N, Manandhar, B, Singh, SK, Gupta, G, Wich, PR, Nammi, S, MacLoughlin, R, Adams, J, Warkiani, ME, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K, 'Attenuation of Cigarette-Smoke-Induced Oxidative Stress, Senescence, and Inflammation by Berberine-Loaded Liquid Crystalline Nanoparticles: In Vitro Study in 16HBE and RAW264.7 Cells', Antioxidants, vol. 11, no. 5, pp. 873-873.
View/Download from: Publisher's site

FOR Codes: Human Pharmaceutical Products, Pharmacology and pharmaceutical sciences, Pharmaceutical delivery technologies