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Homogenous Antibody-Metal Conjugates For Immuno-Mass Spectrometry Imaging

Funding: 2023: $140,476
2024: $145,774
2025: $156,383

Project Member(s): Bishop, D., McDonagh, A.

Funding or Partner Organisation: Australian Research Council (ARC Discovery Projects)
Australian Research Council (ARC Discovery Projects)

Start year: 2023

Summary: This project aims to address current shortcomings in approaches that visualise and measure proteins in cells and tissue using bespoke metal labels and high-resolution mass spectrometry imaging. It expects to increase the utility of 'immuno-mass spectrometry imaging' technology to analyses that are refractory to current techniques and workflows. Expected outcomes include metal probes that facilitate the spatial quantification of multiple biomolecules on a single histological section, providing significant benefits to bioscience laboratories that require complex workflows to obtain the same information.


Mello, MG, Westerhausen, MT, Lockwood, TE, Singh, P, Wanagat, J & Bishop, DP 2024, 'Immunolabelling perturbs the endogenous and antibody-conjugated elemental concentrations during immuno-mass spectrometry imaging', Analytical and Bioanalytical Chemistry, vol. 416, no. 11, pp. 2725-2735.
View/Download from: Publisher's site

FOR Codes: Analytical spectrometry, Bioassays, Expanding knowledge in the biological sciences, Expanding knowledge in the chemical sciences