Targeted delivery of Berberine engineered nanoparticles as a therapeutic intervention for influenza infection in COPD

Project Member(s): Dua, K., Oliver, B., Hansbro, P., Paudel, K., Adams, J.

Funding or Partner Organisation: Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) (SPHERE - TRIPLE I Clinical Academic Group)
Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) (SPHERE - TRIPLE I Clinical Academic Group)

Start year: 2022

Summary: In our previously funded SPHERE seed funding grant, we aimed to develop nanoparticles to deliver berberine as potential therapeutic intervention for influenza infection in COPD. As we progress with this study, we would now like to apply for this extension grant to investigate the efficacy of berberine-loaded nanoparticles in other in-vitro models of respiratory diseases, including asthma and pulmonary fibrosis. For this, we will establish the in-vitro house dust mite-exposed allergic asthma and bleomycin-exposed pulmonary fibrosis model in human bronchoepithelial cell line. The data collected with our seed funding, and presented in our recent publication (https://www.mdpi.com/2076-3921/11/5/873), demonstrate potent anti-inflammatory, anti-oxidative and anti-senescence activity of berberine nanoparticles in cigarette smoke-induced in-vitro model of COPD. As inflammation, oxidative stress, and senescence are also features in the pathophysiology of asthma and pulmonary fibrosis, we expect to observe similar efficacy of berberine nanoparticles.

Publications:

De Rubis, G, Paudel, KR, Allam, VSRR, Malyla, V, Subramaniyan, V, Singh, SK, Panth, N, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2024, 'Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles', Pathology - Research and Practice, vol. 253, pp. 154971-154971.
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Jessamine, V, Mehndiratta, S, De Rubis, G, Paudel, KR, Shetty, S, Suares, D, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K 2024, 'The application of nanoparticles as advanced drug delivery systems in Attenuating COPD', Heliyon, vol. 10, no. 3, pp. e25393-e25393.
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Kokkinis, S, Singh, M, Paudel, KR, De Rubis, G, Bani Saeid, A, Jessamine, V, Datsyuk, J, Singh, SK, Vishwas, S, Adams, J, Hansbro, PM, Oliver, B, Gupta, G, Dureja, H & Dua, K 2024, 'Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges', Food Bioscience, vol. 58, pp. 103761-103761.
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Saeid, AB, De Rubis, G, Williams, KA, Yeung, S, Chellappan, DK, Singh, SK, Gupta, G, Hansbro, PM, Shahbazi, M-A, Gulati, M, Kaur, IP, Santos, HA, Paudel, KR & Dua, K 2024, 'Revolutionising Lung Health: Exploring the Latest Breakthroughs and Future Prospects of Synbiotic Nanostructures in Lung Diseases', Chemico-Biological Interactions, pp. 111009-111009.
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Bani Saeid, A, Patel, VK, Mehndiratta, S, Rajput, R, Kundu, RK, Singh, SK, Chellappan, DK, Kokkinis, S, De Rubis, G, Collet, T, Paudel, KR, Hansbro, PM & Dua, K 2023, 'Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases', Food Bioscience, vol. 56, pp. 103205-103205.
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Chakraborty, A, Paudel, KR, Wang, C, De Rubis, G, Chellappan, DK, Hansbro, PM, Samuel, CS & Dua, K 2023, 'Anti-inflammatory and anti-fibrotic effects of berberine-loaded liquid crystalline nanoparticles.', EXCLI J, vol. 22, pp. 1104-1108.
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De Rubis, G, Paudel, KR, Liu, G, Agarwal, V, MacLoughlin, R, de Jesus Andreoli Pinto, T, Singh, SK, Adams, J, Nammi, S, Chellappan, DK, Oliver, BGG, Hansbro, PM & Dua, K 2023, 'Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells', Toxicology in Vitro, vol. 92, pp. 105660-105660.
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Malyla, V, De Rubis, G, Paudel, KR, Chellappan, DK, Hansbro, NG, Hansbro, PM & Dua, K 2023, 'Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 396, no. 12, pp. 3595-3603.
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Patel, VK, Vishwas, S, Kumar, R, De Rubis, G, Shukla, SD, Paudel, KR, Manandhar, B, Singh, TG, Chellappan, DK, Gulati, M, Kaur, IP, Allam, VSRR, Hansbro, PM, Oliver, BG, MacLoughlin, R, Singh, SK & Dua, K 2023, 'Tackling the cytokine storm using advanced drug delivery in allergic airway disease', Journal of Drug Delivery Science and Technology, vol. 82, pp. 104366-104366.
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De Rubis, G, Paudel, KR & Dua, K 2023, 'Modernizing traditional medicine: nanoparticle-based drug delivery systems to improve the delivery of phytoceuticals in managing chronic respiratory diseases'.

De Rubis, G, Paudel, KR, Liu, G, Hansbro, P, Adams, J, Oliver, B & Dua, K 2023, 'Berberine-loaded nanoparticles attenuate TGF-β-induced remodelling features in human bronchial epithelial cells'.

Paudel, KR, Manandhar, B, Singh, SK, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2023, 'Cytotoxic mechanisms of berberine-phytantriol liquid crystalline nanoparticles against non-small-cell lung cancer.', IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, pp. 516-519.
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Chellappan, DK, Paudel, KR, Tan, NW, Cheong, KS, Khoo, SSQ, Seow, SM, Chellian, J, Candasamy, M, Patel, VK, Arora, P, Singh, PK, Singh, SK, Gupta, G, Oliver, BG, Hansbro, PM & Dua, K 2022, 'Targeting the mitochondria in chronic respiratory diseases', Mitochondrion, vol. 67, pp. 15-37.
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Clarence, DD, Paudel, KR, Manandhar, B, Singh, SK, Devkota, HP, Panneerselvam, J, Gupta, V, Chitranshi, N, Verma, N, Saad, S, Gupta, G, Hansbro, PM, Oliver, BG, Madheswaran, T, Dua, K & Chellappan, DK, 'Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases', Nutrients, vol. 14, no. 18, pp. 3828-3828.
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FOR Codes: Human pharmaceutical products, Pharmacology and pharmaceutical sciences, Immunology, Respiratory diseases

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.