Building a non-coding RNA system biology network to identify mechanistic pathways in oral cancers Project

Project Member(s): Tran, N.

Funding or Partner Organisation: The Garnett Passe and Rodney Williams Memorial Foundation (The Garnett Passe and Rodney Williams Memorial Foundation - Project Grants/ Fellowships)
The Garnett Passe and Rodney Williams Memorial Foundation (The Garnett Passe and Rodney Williams Memorial Foundation - Project Grants/ Fellowships)

Start year: 2023

Summary: Head and Neck cancers are caused by major events in gene regulation. There is an underlying system of regulation that can control this entire gene ecosystem. These are small RNAs known as microRNAs, and they are the master's regulators controlling most of the genes in a cell. MicroRNA can also influence the expression of other microRNAs, and this self-regulation can have a profound impact on normal healthy cells. Our project will determine how these microRNAs can regulate each other and how this may transform healthy cells into cancerous entities. With this information, we can understand which gene events are important for the causation of these cancers. It may aid in the clinical development of new therapies to target these molecular pathways.

FOR Codes: Cancer cell biology, Systems biology, Expanding knowledge in the biomedical and clinical sciences

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.