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Towards a peptide-based adjuvant drug to reduce the toxicity of Amphotericin B in the treatment of invasive fungal infections

Project Member(s): Deplazes, E., Hartmann, L., Cranfield, C.

Funding or Partner Organisation: Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) (SPHERE - TRIPLE I Clinical Academic Group)
Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) (SPHERE - TRIPLE I Clinical Academic Group)

Start year: 2023

Summary: This exchange aims to establish a collaboration between Dr Megan Lenardon, an expert in fungal cell wall biology at UNSW, and A/Prof Charles Cranfield and Dr Evelyne Deplazes, experts in membrane biophysics at UTS and UQ. The project aims to carry out microscopy experiments at UTS to study the cell wall permeation of a peptide that increases the activity of a potent but toxic drug to treat life-threatening invasive fungal infections.

FOR Codes: Biologically active molecules, Proteins and peptides, Biochemistry and cell biology, Expanding knowledge in the biomedical and clinical sciences, Expanding knowledge in the biological sciences, Expanding knowledge in the chemical sciences