Engineering Bed-Rest-in-a-Dish to Discover the Therapeutic Strategies to Promote Dynamic Resilience in Older Adults

Project Member(s): Philp, A.

Funding or Partner Organisation: Wellcome Leap Inc
Wellcome Leap Inc

Start year: 2023

Summary: Objective 1 – Utilising short-term unloading of young, old healthy and old sarcopenic micro-muscles, we will decipher the mechanisms of inactivity mediated muscle wasting. Objective 2 – Develop a bed-rest-in-a-dish platform by exposing young and old healthy/sarcopenic micromuscles to systemic inflammation/oxidative stress (patient blood samples) and unloading. Objective 3 – Utilising phospho-proteomics and RNA-Seq transcriptomics, we will profile the molecular pathways regulating dynamic resilience on young and old healthy/sarcopenic micro muscles, to identify 3 lead therapeutic targets to prevent muscle deterioration during bed rest conditions.

FOR Codes: Sports science and exercise, Sport, exercise and recreation

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.