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Identification and Development of Potential Novel Therapeutic Interventions for Influenza A Virus (IAV) infection in Chronic Obstructive Pulmonary Disease (COPD)

Start year: 2023

Summary: COPD is characterised by airflow obstruction, shortness of breath, coughing, chest tightness and wheezing. Viral respiratory infections are the most common triggers of COPD exacerbations in adults (76%) and children (80-85%), resulting in significant worsening of disease symptoms, negatively impacting the quality of life, and prolonged hospitalisation leading to significant healthcare costs. Current approaches to control COPD disease features include the use of bronchodilators and inhalational corticosteroids (ICS) [3]. However, these approaches are poorly effective in managing COPD exacerbations, leading to the need of novel therapeutic interventions