NF-kB decoy oligonucleotide-loaded functionalized nanoparticles as a novel therapeutic intervention in asthma

Start year: 2024

Summary: We hypothesize that encapsulating an NF-kB decoy ODN in engineered nanoparticles has potential to reduce airway inflammation in asthma. In this context, we aim at developing NF-kB decoy ODN-loaded Spermine-functionalized Acetalated Dextran Nanoparticles (SpAcDeX-NPs) to deliver the NF-kB Decoy ODN to LPS-stimulated mouse macrophage cells (RAW264.7), a commonly used in vitro model of LPS-induced inflammation.

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.