Utilising the potential of quercetin solid lipid nanoparticles to induce immunogenic cell death as a novel strategy for lung cancer treatment

Start year: 2024

Summary: Several phytoceuticals such as resveratrol, curcumin etc. have been reported to induce immunogenic cell death. Quercetin is one another well explored natural compound with reported anticancer and anti-inflammatory properties however suffers from poor bioavailability. Furthermore, ICD inducing potential of quercetin remains vaguely unexplored. Therefore, we hypothesise that encapsulating quercetin in engineered nanoparticles will improve its bioavailability and targeted delivery. By means, we aim to develop quercetin-loaded solid lipid nanoparticles (SLN) to study the delivery of quercetin as an effective therapeutic intervention to induce ICD in lung cancer cells.