A new indicator of platelet reactivity in cardiovascular disease

Start year: 2025

Summary: Haemostasis is a complex interplay of the vascular endothelium, platelets, and coagulation factors to arrest bleeding. This process may lead to thrombosis and obstruction of coronary blood vessels. Individuals with a heightened tendency to form thrombi have an accelerated development of atherosclerosis and are at increased risk of acute coronary syndrome and myocardial infarction. Understanding the molecular basis of thrombosis is necessary for mitigating lifetime cardiovascular disease risk and effective application of existing and new anti-thrombotic drugs. This program of research will explore an entirely novel indicator of platelet reactivity in cardiovascular disease. Should the hypothesis prove to be correct, measurement of this indicator will inform thrombotic potential in cardiovascular disease.