Ultrasensitive microRNA detection for early-stage breast cancer diagnostics

Project Member(s): Bao, G., McNevin, D.

Funding or Partner Organisation: The trustee for Tour De Cure Trust (Tour De Cure - Early Career Research Grants)
The trustee for Tour De Cure Trust (Tour De Cure - Early Career Research Grants)

Start year: 2025

Summary: This project aims to create superbright nanoprobes, with high brightness and low background noise, for the ultrasensitive detection of microRNA. It will centre on developing near-infrared dyes with aggregation-induced emission properties and resistance to photobleaching to overcome concentration quenching in dye-sensitised nanomaterials. hybrid upconversion system to amplify the brightness of upconversion nanoparticles. I will apply the stable superbright nanoprobes developed for single molecule detection of microRNA 21 and achieve an efficient early-stage diagnosis of breast cancer.

FOR Codes: Prevention of human diseases and conditions, Expanding knowledge in the chemical sciences, Expanding knowledge in the health sciences, Expanding knowledge in the biomedical and clinical sciences, Inorganic materials (incl. nanomaterials), Biomedical engineering

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.