Disulfide Bond Modulation of Prothrombin in Antiphospholipid Syndrome

Start year: 2025

Summary: This project aligns closely with my ongoing research on the functional characteristics of disulphide-bonded forms of prothrombin. My current work focuses on understanding the fundamental differences between these structural variants and elucidating why prothrombin is expressed in multiple forms under healthy physiological conditions. The proposed grant project complements this by extending the investigation into a translational context, exploring how structural heterogeneity in prothrombin contributes to autoimmune targeting and thrombotic risk in APS. Together, these studies provide a comprehensive framework bridging basic mechanistic insights with clinically relevant outcomes.

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.