Acharya, M, Singh, N, Gupta, G, Tambuwala, MM, Aljabali, AAA, Chellappan, DK, Dua, K & Goyal, R 2024, 'Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection', Cellular Signalling, vol. 116, pp. 111043-111043.
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Bangar, A, Khan, H, Kaur, A, Dua, K & Singh, TG 2024, 'Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury', Journal of Ethnopharmacology, vol. 319, pp. 117153-117153.
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ETHNOPHARMACOLOGICAL RELEVANCE: Stroke is one of the leading causes of death and disability. The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA), exhibiting a short therapeutic window. Due to this reason, only a small number of patients can be benefitted in this critical period. In addition, the use of endovascular interventions may reverse vessel occlusion more effectively and thus help further improve outcomes in experimental stroke. During recovery of blood flow after ischemia, patients experience cognitive, behavioral, affective, emotional, and electrophysiological changes. Therefore, it became the need for an hour to discover a novel strategy for managing stroke. The drug discovery process has focused on developing herbal medicines with neuroprotective effects via modulating neuroplasticity. AIM OF THE STUDY: We gather and highlight the most essential traditional understanding of therapeutic plants and their efficacy in cerebral ischemia-reperfusion injury. In addition, we provide a concise summary and explanation of herbal drugs and their role in improving neuroplasticity. We review the pharmacological activity of polyherbal formulations produced from some of the most frequently referenced botanicals for the treatment of cerebral ischemia damage. MATERIALS AND METHODS: A systematic literature review of bentham, scopus, pubmed, medline, and embase (elsevier) databases was carried out with the help of the keywords like neuroplasticity, herbal drugs, neural progenitor cells, neuroprotection, stem cells. The review was conducted using the above keywords to understand the therapeutic and mechanistic role of herbal neuroprotective agents on neuroplasticity in cerebral ischemic-reperfusion injury. RESULTS: Neuroplasticity emerged as an alternative to improve recovery and management after cerebral ischemic reperfusion injury. Neuroplasticity is a physiological process throughout one's life in response to any stimuli and...
Baroni, MP, Hespanhol, L, Knaut, SAM, Quartiero, CRB, Pedroso, LS & Saragiotto, BT 2024, 'PAIN NEUROSCIENCE EDUCATION IN THE BRAZILIAN PUBLIC HEALTH SYSTEM: PRE-IMPLEMENTATION PROCESS', Brazilian Journal of Physical Therapy, vol. 28, pp. 100915-100915.
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Baroni, MP, Yocoyama, KDM, Knaut, SAM, Umburanas, RC, Clemente, PA & Saragiotto, BT 2024, 'ORGANIZATION OF PRIMARY HEALTHCARE FOR USERS WITH CHRONIC MUSCULOSKELETAL PAIN BY PROGNOSTIC STRATIFICATION', Brazilian Journal of Physical Therapy, vol. 28, pp. 100914-100914.
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Bashir, B, Alam, S, Khandale, N, Birla, D, Vishwas, S, Pandey, NK, Gupta, G, Paudel, KR, Dureja, H, Kumar, P, Singh, TG, Kuppusamy, G, Zacconi, FC, Pinto, TDJA, Dhanasekaran, M, Gulati, M, Dua, K & Singh, SK 2024, 'Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation', Ageing Research Reviews, vol. 95, pp. 102236-102236.
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Bashir, B, Mittal, S, Muthukumar, A, Vishwas, S, Pandey, NK, Gulati, M, Gupta, G, Dhanasekaran, M, Kumar, P, Dureja, H, Veiga, F, Paiva-Santos, AC, Adams, J, Dua, K & Singh, SK 2024, 'Harnessing the neuroprotective effect of oral administration of benfotiamine in MPTP induced Parkinson's disease in rats', European Journal of Pharmacology, vol. 962, pp. 176234-176234.
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The study was performed to evaluate the neuroprotective effects of Benfotiamine (BFT) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) in rats. The rats were given daily doses of BFT (100mg/kg, 200mg/kg) through oral administration for 42 days. The rats were given a single bilateral dosage of MPTP (0.1 mg/nostril) intranasally once before the drug treatment to induce PD. On day 42, the animals were subjected to various behavioral paradigms. Post-treatment with BFT for 42 days significantly improved the motor and nonmotor fluctuations of MPTP. The results demonstrated that treatment with BFT ameliorated MPTP-induced disorders in behavior, body balance, and dopamine levels in the mid-brain. Among the post-treated groups, a high dose of BFT was the most effective treatment. Mean values are indicated in ±SEM, n = 5***(p < 0.001) when compared with the vehicle control, n = 5 ### (p < 0.001) when compared with the disease control; (p < 0.001) when compared with the BFT per se; (p < 0.001) when compared with the low dose of BFT; (p < 0.001) when compared with the high dose of BFT. Our finding suggests that BFT contributed to superior antioxidant, and anti-inflammatory and could be a novel therapeutic method for PD management. In conclusion, BFT could be a potential drug candidate for curbing and preventing PD.
Bhat, AA, Afzal, M, Goyal, A, Gupta, G, Thapa, R, almalki, WH, Kazmi, I, Alzarea, SI, Shahwan, M, Paudel, KR, Ali, H, Sahu, D, Prasher, P, Singh, SK & Dua, K 2024, 'The Impact of Formaldehyde Exposure on Lung Inflammatory Disorders: Insights into Asthma, Bronchitis, and Pulmonary Fibrosis', Chemico-Biological Interactions, pp. 111002-111002.
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Bhat, AA, Gupta, G, Dahiya, R, Thapa, R, Gahtori, A, Shahwan, M, Jakhmola, V, Tiwari, A, Kumar, M, Dureja, H, Singh, SK, Dua, K, Kumarasamy, V & Subramaniyan, V 2024, 'CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis', Non-coding RNA Research, vol. 9, no. 2, pp. 277-287.
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Bhat, AA, Riadi, Y, Afzal, M, Bansal, P, Kaur, H, Deorari, M, Ali, H, Shahwan, M, almalki, WH, Kazmi, I, Alzarea, SI, Dureja, H, Singh, SK, Dua, K & Gupta, G 2024, 'Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis', Pathology - Research and Practice, vol. 256, pp. 155224-155224.
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Bowman, SJ, Hakeem, A, Demant, D, McAloon, J & Wootton, BM 2024, 'Assessing Gender Dysphoria: Development and Validation of the Gender Preoccupation and Stability Questionnaire – 2 nd Edition (GPSQ-2)', Journal of Homosexuality, vol. 71, no. 3, pp. 666-690.
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The Gender Preoccupation and Stability Questionnaire (GPSQ) is a 14-item measure used to assess the effectiveness of medical, surgical, social, and psychological interventions in trans and gender diverse adults who experience gender dysphoria. One major limitation of the GPSQ is that it was not developed for use with adolescents. This study aims to validate a revised version of the GPSQ, the Gender Preoccupation and Stability Questionnaire-2nd Edition (GPSQ-2) with the aim of adapting the measure to be applicable to individuals aged 13 and above. This research was conducted in three stages: 1) development of the GPSQ-2 to address previously identified issues with validity and comprehensibility of the GPSQ and to increase the applicability of the measure to adolescents; 2) pilot testing, using a purposive sample and semi-structured interviews, to assess the relevance, comprehensibility, and comprehensiveness of the GPSQ-2; and 3) validation using a community sample to assess the psychometric properties of the GPSQ-2. The pilot study was conducted with seven participants (Mage = 28.43, SD = 15.50; age range: 13-59). The GPSQ-2 was found to be easy to understand, relevant to individuals who experienced gender dysphoria, and that it did not have any identifiable omissions. The validation study was conducted with 141 participants (Mage = 36.44; SD = 14.76; age range 14-73). The GPSQ-2 was found to be a reliable and valid 14-item scale with two factors: preoccupation and stability. The GPSQ-2 is a structurally sound measure of gender dysphoria that can be used in populations aged 13 and above.
Brunner, M, Rietdijk, R, Summers, K, Southwell, K, Avramovic, P, Power, E, Miao, M, Rushworth, N, MacLean, L, Brookes, A & Togher, L 2024, '‘It gives you encouragement because you're not alone’: A pilot study of a multi‐component social media skills intervention for people with acquired brain injury', International Journal of Language & Communication Disorders, vol. 59, no. 2, pp. 543-558.
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AbstractBackgroundPeople with an acquired brain injury (ABI) find it challenging to use social media due to changes in their cognition and communication skills. Using social media can provide opportunities for positive connection, but there is a lack of interventions specifically designed to support safe and successful social media use after ABI.AimsTo investigate the outcomes of completing a social media skills intervention and identify barriers and facilitators for future implementation.Methods & ProceduresThe study used a mixed‐methods, pre‐post‐intervention design. A total of 17 adults with an ABI were recruited. Participants completed an intervention that included a short self‐guided course about social media skills (social‐ABI‐lity course), and then participated in a private, moderated Facebook group over a 12‐week period (social‐ABI‐lity Facebook group). Data were collected over this period through observation of group activity and weekly surveys. They were also collected on social media use and quality of life at pre‐intervention, post‐intervention and after 3 months. Participants provided feedback on the experience of participating in the programme via a post‐intervention interview.Outcomes & ResultsAt post‐intervention, there were significant improvements in confidence in using Facebook (p = 0.002) and enjoyment of using Facebook to connect with others (p = 0.013). There was no significant change in reported quality of life, although participants described the multiple benefits of connection they perceived from involvement in the group. Observational data and feedback interviews were informative about the feasibility and acceptabi...
Bryant, L & Hemsley, B 2024, 'Augmented reality: a view to future visual supports for people with disability', Disability and Rehabilitation: Assistive Technology, vol. 19, no. 3, pp. 800-813.
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Background: Augmented reality (AR) technologies may provide immersive visual supports that foster active user engagement in activities. However, there is little research examining the use of AR as a visual support to guide its use in research or therapy settings.Aims: To investigate the development and use of AR for delivering visual supports in an immersive environment, using the Microsoft® HoloLens2® and Microsoft® Dynamics 365 Guides® software.Method: In a duo-ethnography, two speech-language pathologists who were novice users of the HoloLens2®, examined the affordances of the device for potential use in future research with people with neurodevelopmental disability. In a proof-of-concept study, an AR application was designed by the first author and used by two researchers in a duo-ethnography. The first and second author tested the AR guide and reflected on opportunities and barriers to further use of AR technology, specifically the HoloLens2®, to support people with disability to participate and be included in meaningful activities.Results: The guide created provided situated visual instructions, video models, and holographic symbols to direct the second author in making of a cup of tea. While a moderate level of technological literacy was needed to establish and install a guide, effective use could be established with minimal training.Discussion & conclusions: AR guides offer a situated and integrated means of providing visual support to people with disabilities. This proof-of-concept study justifies further testing and evaluation of AR as an assistive technology for people with neurodevelopmental disability.IMPLICATIONS FOR REHABILITATIONEmerging immersive Augmented Reality technology provides new opportunities to create integrated visual supports that function within the user's environment to enable active participation in activities and interactions.Visual supports integrated with the user's environment may better support people with disability...
Bryant, L, Sedlarevic, N, Stubbs, P, Bailey, B, Nguyen, V, Bluff, A, Barnett, D, Estela, M, Hayes, C, Jacobs, C, Kneebone, I, Lucas, C, Mehta, P, Power, E & Hemsley, B 2024, 'Collaborative co-design and evaluation of an immersive virtual reality application prototype for communication rehabilitation (DISCOVR prototype)', Disability and Rehabilitation: Assistive Technology, vol. 19, no. 1, pp. 90-99.
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PURPOSE: Virtual reality (VR) lends itself to communication rehabilitation by creating safe, replicable, and authentic simulated environments in which users learn and practice communication skills. The aim of this research was to obtain the views of health professionals and technology specialists on the design characteristics and usability of a prototype VR application for communication rehabilitation. MATERIALS AND METHODS: Nine professionals from different health and technology disciplines participated in an online focus group or individual online interview to evaluate the application and use of the VR prototype. Data sources were analysed using a content thematic analysis. RESULTS: Four main themes relating to VR design and implementation in rehabilitation were identified: (i) designing rehabilitation-focused virtual worlds; (ii) understanding and using VR hardware; (iii) making room for VR in rehabilitation and training; and (iv) implementing VR will not replace the health professional's role. DISCUSSION: Health professionals and technology specialists engaged in co-design while evaluating the VR prototype. They identified software features requiring careful consideration to ensure improved usability, client safety, and success in communication rehabilitation outcomes. Continuing inclusive co-design, engaging health professionals, clients with communication disability, and their families will be essential to creating useable VR applications and integrating these successfully into rehabilitation. Implications for rehabilitationHealth and technology professionals, along with clients, are integral to the co-design of new VR technology applications.Design of VR applications needs to consider the client's communication, physical, cognitive, sensory, psychosocial, and emotional needs for greater usability of these programs.Realism and authenticity of interactions, characters, and environments are considered important factors to allow users to be fully immersed in v...
Burley, J & McAloon, J 2024, 'Group acceptance and commitment therapy for adolescent anxiety: A systematic review and meta-analysis', Journal of Contextual Behavioral Science, vol. 31, pp. 100712-100712.
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Chan, M, Ghadieh, C, Irfan, I, Khair, E, Padilla, N, Rebeiro, S, Sidgreaves, A, Patravale, V, Disouza, J, Catanzariti, R, Pont, L, Williams, K, De Rubis, G, Mehndiratta, S, Dhanasekaran, M & Dua, K 2024, 'Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 2, pp. 751-762.
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AbstractThe microbiome is increasingly implicated in playing a role in physiology and pharmacology; in this review, we investigate the literature on the possibility of bacterial influence on the pharmacology of anti-asthmatic drugs, and the potential impact this has on asthmatic patients. Current knowledge in this area of research reveals an interaction between the gut and lung microbiome and the development of asthma. The influence of microbiome on the pharmacokinetics and pharmacodynamics of anti-asthmatic drugs is limited; however, understanding this interaction will assist in creating a more efficient treatment approach. This literature review highlighted that bioaccumulation and biotransformation in the presence of certain gut bacterial strains could affect drug metabolism in anti-asthmatic drugs. Furthermore, the bacterial richness in the lungs and the gut can influence drug efficacy and could also play a role in drug response. The implications of the above findings suggest that the microbiome is a contributing factor to an individuals’ pharmacological response to anti-asthmatic drugs. Hence, future directions for research should follow investigating how these processes affect asthmatic patients and consider the role of the microbiome on drug efficacy and modify treatment guidelines accordingly.
Chen, H-Y, Möller, H, Senserrick, TM, Rogers, KD, Cullen, P & Ivers, RQ 2024, 'Young drivers’ early access to their own car and crash risk into early adulthood: Findings from the DRIVE study', Accident Analysis & Prevention, vol. 199, pp. 107516-107516.
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Clayton, NA, Freeman-Sanderson, A & Walker, E 2024, 'Dysphagia Prevalence and Outcomes Associated with the Evolution of COVID-19 and Its Variants in Critically Ill Patients', Dysphagia, vol. 39, no. 1, pp. 109-118.
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AbstractData collected during the 2020–21 COVID-19 alpha wave indicated dysphagia prevalence rates up to 93%. Whilst many patients recovered during hospital admission, some experienced persistent dysphagia with protracted recovery. To explore (1) prevalence, (2) treatment, and (3) recovery patterns and outcomes for swallowing, in the ICU patient with Delta and subsequent variants of COVID-19. Prospective observational study. Patients admitted to 26 Intensive Care Units (ICUs) over 12 months, diagnosed with COVID-19, treated for survival and seen by Speech–Language Pathology (SLP) for clinical swallowing assessment were included. Demographic, medical, SLP treatment, and swallowing outcome data were collected. 235 participants (63% male, median age = 58 years) were recruited. Median mechanical ventilation was 16 days, and ICU and hospital length of stay (LOS) were 20 and 42 days, respectively. ICU-Acquired Weakness (54%) and delirium (49%) were frequently observed. Prevalence of dysphagia was 94% with the majority (45%) exhibiting profound dysphagia (Functional Oral Intake Scale = 1) at initial assessment. Median duration to initiate oral feeding was 19 days (IQR = 11-44 days) from ICU admission, and 24% received dysphagia rehabilitation. Dysphagia recovery by hospital discharge was observed in 71% (median duration = 30 days [IQR = 17-56 days]). Positive linear associations were identified between duration of intubation, mechanical ventilation, hospital and ICU LOS, and duration to SLP assessment (p = 0.000), dysphagia severity (p = 0.000), commencing oral intake (p = 0.000), dysphagia recovery (p < 0.01), and enteral feeding (p = 0.000). Whilst older participants had more severe dysphagia (p = 0.028), younger participants took longer to commence oral feeding (...
Clayton, NA, Freeman-Sanderson, A & Walker, E 2024, 'Prevalence and recovery of dysphonia in COVID-19 patients requiring intensive care treatment', Australian Critical Care, vol. 37, no. 1, pp. 151-157.
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Correia, I, Meziat-Filho, N, Furlan, AD, Saragiotto, B & Reis, FJJ 2024, 'Are we missing the opioid consumption in low- and middle-income countries?', Scandinavian Journal of Pain, vol. 24, no. 1.
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Abstract Objectives The rise in opioid prescriptions with a parallel increase in opioid use disorders remains a significant challenge in some developed countries (opioid epidemic). However, little is known about opioid consumption in low- and middle-income countries (LMICs). In this short report, we aim to discuss the increase in opioid consumption in LMICs by providing an update on the opioid perspective in Brazil. Methods We analyzed opioid sales on the publicly available Brazilian Health Regulatory Agency (ANVISA) database from 2015 to 2020. Results In Brazil, opioid sales increased 34.8 %, from 8,839,029 prescriptions in 2015 to 11,913,823 prescriptions in 2020, this represents an increase from 44 to 56 prescriptions for every 1,000 inhabitants. Codeine phosphate combined with paracetamol and tramadol hydrochloride were the most common opioids prescribed with an increase each year. Conclusions The results suggest that opioid prescriptions are rising in Brazil in a 5 years period. Brazil may have a unique opportunity to learn from other countries and develop consistent policies and guidelines to better educate patients and prescribers and to prevent an opioid crisis.
Crumlish, L, Copley, A, Wallace, SJ & Rose, TA 2024, 'Barriers and facilitators to the assessment of cognitive-communication disorders in children and adolescents after traumatic brain injury: a survey of Australian clinical practice', Brain Impairment, vol. 25, no. 1.
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De Rubis, G, Paudel, KR, Allam, VSRR, Malyla, V, Subramaniyan, V, Singh, SK, Panth, N, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2024, 'Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles', Pathology - Research and Practice, vol. 253, pp. 154971-154971.
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De Rubis, G, Paudel, KR, Yeung, S, Agarwal, V, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Ribavirin attenuates carcinogenesis by downregulating IL-6 and IL-8 in vitro in human lung adenocarcinoma', Pathology - Research and Practice, vol. 253, pp. 155038-155038.
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De Rubis, G, Paudel, KR, Yeung, S, Mohamad, S, Sudhakar, S, Singh, SK, Gupta, G, Hansbro, PM, Chellappan, DK, Oliver, BGG & Dua, K 2024, '18-β-glycyrrhetinic acid-loaded polymeric nanoparticles attenuate cigarette smoke-induced markers of impaired antiviral response in vitro', Pathology - Research and Practice, pp. 155295-155295.
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Denson, TF, Watson, P, Yeong, A, Armstrong, A, Beames, JR & Bertsch, K 2024, 'Eye tracking shows no substantive relationships between individual differences related to aggression and visual attention to unambiguously violent stimuli', Personality and Individual Differences, vol. 217, pp. 112425-112425.
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Eiger, B, Straszek, CL, Pate, JW & Rathleff, MS 2024, 'Translation, contextual adaptation, and reliability of the Danish Concept of Pain Inventory (COPI-Adult (DK)) – A self-reported outcome measure', Scandinavian Journal of Pain, vol. 24, no. 1.
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Abstract Objectives Pain is a growing concern globally, and an individual and societal burden. Pain science education (PSE) is a promising avenue for managing chronic pain, but targeted PSE is needed. The Concept of Pain Inventory for Adults (COPI-Adult) is a newly developed self-reported outcome measure aimed at targeting PSE. It is currently unavailable in Danish and has unknown reliability. The aims of this study were (1) to translate and contextually adapt to Danish and (2) to determine reliability in terms of test–retest reliability, internal consistency, and measurement error. Methods Step (1) was as follows: a dual panel approach was used to translate, contextually adapt into a Danish version. Step (2) was follows: a heterogenic sample of Danish adults >18 years (n = 150) was included in the test–retest analysis, test interval between 7 and 14 days, both answered via REDCap-link. Based on COSMIN recommendations, the following reliabilities were estimated: the test–retest using intraclass correlation coefficient (ICC2.1) and internal consistency using Cronbach’s alpha level. Measurement error in terms of standard error of measurement (SEM) and smallest detectable change (SDC) were calculated. Results Step (1) was as follows: the first panel reached 100% consensus on the wording of the COPI-Adult (DK), with no alterations by the second panel. Step (2) was as follows: good to excellent test–retest reliability was found with ICC2.1 value (95% confidence interval) 0.88 (0.84–0.91), excellent internal consi...
Fandim, J & Saragiotto, B 2024, 'NOT FROM THE START, BUT IN TIME! SHAPING CONSENSUS ON TERMINOLOGY AND RESEARCH PRIORITIES IN TELEHEALTH IN MUSCULOSKELETAL PAIN', Brazilian Journal of Physical Therapy, vol. 28, pp. 100821-100821.
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Fisher, G, Quel de Oliveira, C, Stubbs, PW, Power, E, Checketts, M, Porter-Armstrong, A & Kennedy, DS 2024, 'Spatial Neglect: An Exploration of Clinical Assessment Behaviour in Stroke Rehabilitation', Clinical Rehabilitation, vol. 38, no. 5, pp. 688-699.
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Objective There is a large gap between evidence-based recommendations for spatial neglect assessment and clinical practice in stroke rehabilitation. We aimed to describe factors that may contribute to this gap, clinician perceptions of an ideal assessment tool, and potential implementation strategies to change clinical practice in this area. Design Qualitative focus group investigation. Focus group questions were mapped to the Theoretical Domains Framework and asked participants to describe their experiences and perceptions of spatial neglect assessment. Setting Online stroke rehabilitation educational bootcamp. Participants A sample of 23 occupational therapists, three physiotherapists, and one orthoptist that attended the bootcamp. Intervention Prior to their focus group, participants watched an hour-long educational session about spatial neglect. Main measures A deductive analysis with the Theoretical Domains Framework was used to describe perceived determinants of clinical spatial neglect assessment. An inductive thematic analysis was used to describe perceptions of an ideal assessment tool and practice-change strategies in this area. Results Participants reported that their choice of spatial neglect assessment was influenced by a belief that it would positively impact the function of people with stroke. However, a lack of knowledge about spatial neglect assessment appeared to drive low clinical use of standardised functional assessments. Participants recommended open-source online education involving a multidisciplinary team, with live...
Folder, N, Power, E, Rietdijk, R, Christensen, I, Togher, L & Parker, D 2024, 'The Effectiveness and Characteristics of Communication Partner Training Programs for Families of People With Dementia: A Systematic Review', The Gerontologist, vol. 64, no. 4, p. gnad095.
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Abstract Background and Objectives Communication partner training (CPT) is essential in dementia care. Despite families being the largest group of community carers, previous reviews primarily focused on formal carers. This study aimed to understand the characteristics and effectiveness of CPT for families of people with dementia. Research Design and Methods The systematic review included intervention/protocol studies on dementia CPT for families, excluding formal carers and programs not focused on communication. CINAHL, PsycINFO, SpeechBITE, Medline, SCOPUS, and Embase were searched between November 30 and December 6, 2021. After deduplication, 3,172 records were screened. Quality assessment used JBI Critical Appraisal tools and the Mixed Methods Appraisal Tool. Data synthesis utilized three reporting tools, the International Classification of Functioning, Disability, and Health, and content analysis. Results Of 30 studies (27 programs), there were 10 quasi-experimental, 5 RCTs, 4 mixed methods, 4 case studies, 4 qualitative, and 2 protocols. Studies were published between 1998 and 2021 and included 671 family members. Characteristics varied with 7/27 programs including consumers during creation and one program including telehealth. One study included all reporting tool criteria. Programs typically used 4 intervention functions, with 12/27 programs addressing 3 behavior change areas. 33/74 outcome measures targeted the “Environment” of the person with dementia. Studies showed positive improvements in communication skills and knowledge, with mixed results on behavior/psychosocial...
Garavelis, KN, Hayes, N, Rose, TA, Maloney, M, Liddle, K, Moritz, K, Gullo, M, Gullo, HL, McMah, R, Heussler, H & Reid, N 2024, 'Exploring the experience of service users following attendance at a student-led interprofessional neurodevelopmental clinic', Disability and Rehabilitation, vol. 46, no. 7, pp. 1298-1308.
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Glezakis, K, Burton, AL, Abbott, MJ & Norton, AR 2024, 'Self-concept clarity in social anxiety: psychometric properties and factor structure of the Self-Concept Clarity Scale in a social anxiety disorder sample', Clinical Psychologist, pp. 1-11.
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Background: The Self-Concept Clarity Scale (SCCS) is a 12-item self-report measure that assesses self-concept clarity (SCC). Previous research has identified a relationship between lower SCC and higher levels of social anxiety. As a measure of positive psychological well-being, the SCCS can be used as a tool to examine and monitor SCC in populations with social anxiety disorder (SAD) who appear to be susceptible to inconsistent or unstable self-concept. However, the scale has yet to be validated with a SAD sample. Methods: A confirmatory factor analysis (CFA) was conducted on the SCCS data of sample of 87 individuals who met criteria for a diagnosis of SAD (M = 20.15, SD = 3.55; 83% female) and the reliability, convergent validity and norm scores of the SCCS with a SAD were also investigated. Results: Results of the CFA supported a unidimensional factor structure. The SCCS was found to have good internal consistency (Cronbach’s α =.80) and SCCS scores were found to correlate with measures of psychological distress and social fears, however, no correlation was found with measures of social anxiety behaviours. Also, overall results found that the SAD sample scored lower on SCC than other clinical samples in previous literature. Conclusions: These findings suggest that the SCCS is a psychometrically sound measure with unidimensional factor structure and demonstrated reliability and validity with a SAD sample, although additional research is warranted to replicate and extend the results of the current research.
Grimaldi, A, Mellor, R, Nasser, A, Vicenzino, B & Hunter, DJ 2024, 'Current and future advances in practice: tendinopathies of the hip', Rheumatology Advances in Practice, vol. 8, no. 2.
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Abstract Tendinopathy describes persistent tendon pain and loss of function related to mechanical loading. Two common hip tendinopathies seen in practice are gluteal tendinopathy and proximal hamstring tendinopathy. Both conditions can be frustrating for patients and clinicians due to the delay in diagnosis, significant disability caused and lack of response to common treatments. Tendinopathy is a clinical diagnosis and can most often be made using findings from the patient interview and pain provocation tests, without the need for imaging. Specific education and progressive exercise offer a low-risk and effective option for gluteal tendinopathy and result in greater rates of treatment success than corticosteroid injection, both in the short term (8 weeks) and at 1 year. Proximal hamstring tendinopathy is a common, but less researched, and under-recognized cause of persistent ischial pain. As research on proximal hamstring tendinopathy is limited, this review summarizes the available evidence on diagnosis and treatment following similar principles to other well-researched tendinopathies.
Grunseit, AC, Huang, B-H, Merom, D, Bauman, A, Cranney, L & Rogers, K 2024, 'Patterns and Correlates of Participation in a Weekly Mass Participation Physical Activity Event, parkrun, in Australia, 2011–2020', Journal of Physical Activity and Health, vol. 21, no. 2, pp. 155-163.
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Background: Studying effective interventions already operating at scale is critical to improving physical activity intervention research translation. The free, weekly, timed 5-km run or walk parkrun represents a unique opportunity to examine successful organic dissemination. We conducted an ecological analysis to identify patterns of growth in Australian parkrun participation and their correlates from 2011 to 2020. Method: Outcome variables were (1) weekly counts of walkers/runners and (2) monthly number of new parkrun registrants. We used latent class analysis to characterize growth trajectories followed by logistic regression on class membership. Covariates included parkrun course characteristics (eg, surface type and route), site-level aggregate participant profile (eg, proportion women and mean age), and surrounding area characteristics (eg, population density and physical activity norm). Results: Three hundred and sixty-three parkruns were included (n = 8,388,695 participation instances). Sixty-nine percent followed a low-growth and 31% a high-growth participation pattern. High growth was associated with greater participation by women, concrete/bitumen surface type, lower area socioeconomic status, and greater volunteer heterogeneity. Odds of being in the slow-growth class were higher if the course contained >1 km of repetition, higher average age of participants, better average parkrun performance, and higher running group membership. Two patterns of new registration were identified: high start followed by steep decline; and low start, slow decline with similar correlates to participation. Conclusions
Hemsley, B, Dann, S, Reddacliff, C, Smith, R, Given, F, Gay, V, Leong, TW, Josserand, E, Skellern, K, Bull, C, Palmer, S & Balandin, S 2024, 'Views on the usability, design, and future possibilities of a 3D food printer for people with dysphagia: outcomes of an immersive experience', Disability and Rehabilitation: Assistive Technology, vol. 19, no. 3, pp. 527-536.
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PURPOSE: Although 3D food printing is expected to enable the creation of visually appealing pureed food for people with disability and dysphagia, little is known about the user experience in engaging with 3D food printing or the feasibility of use with populations who need texture-modified foods. The aim of this study was to explore the feasibility and usability of using domestic-scale 3D food printer as an assistive technology to print pureed food into attractive food shapes for people with dysphagia. MATERIALS AND METHODS: In total, 16 participants engaged in the unfamiliar, novel process of using a domestic-scale 3D food printer (choosing, printing, tasting), designed for printing pureed food, and discussed their impressions in focus group or individual interviews. RESULTS AND CONCLUSIONS: Overall, results demonstrated that informed experts who were novice users perceived the 3D food printing process to be fun but time consuming, and that 3D food printers might not yet be suitable for people with dysphagia or their supporters. Slow response time, lack of user feedback, scant detail on the appropriate recipes for the pureed food to create a successful print, and small font on the user panel interface were perceived as barriers to accessibility for people with disability and older people. Participants expected more interactive elements and feedback from the device, particularly in relation to resolving printer or user errors. This study will inform future usability trials and food safety research into 3D printed foods for people with disability and dysphagia. IMPLICATIONS FOR REHABILITATION3D food printers potentially have a role as an assistive technology in the preparation of texture-modified foods for people with disability and dysphagia.To increase feasibility, 3D food printers should be co-designed with people with disability and their supporters and health professionals working in the field of dysphagia and rehabilitation.Experts struggled to be ...
Hussain, MS, Altamimi, ASA, Afzal, M, almalki, WH, Kazmi, I, Alzarea, SI, Saleem, S, Prasher, P, Oliver, B, Singh, SK, MacLoughlin, R, Dua, K & Gupta, G 2024, 'From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer', Pathology - Research and Practice, vol. 253, pp. 155015-155015.
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Hussain, MS, Gupta, G, Mishra, R, Patel, N, Gupta, S, Alzarea, SI, Kazmi, I, Kumbhar, P, Disouza, J, Dureja, H, Kukreti, N, Singh, SK & Dua, K 2024, 'Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer', Pathology - Research and Practice, vol. 255, pp. 155157-155157.
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Hussain, MS, Gupta, G, Samuel, VP, Almalki, WH, Kazmi, I, Alzarea, SI, Saleem, S, Khan, R, Altwaijry, N, Patel, S, Patel, A, Singh, SK & Dua, K 2024, 'Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries', Reviews in Medical Virology, vol. 34, no. 1, p. e2491.
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AbstractThe immunopathology of herpes simplex virus (HSV)‐associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology‐induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV‐associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.
Hussain, MS, Moglad, E, Afzal, M, Bansal, P, Kaur, H, Deorari, M, Ali, H, Shahwan, M, Hassan almalki, W, Kazmi, I, Alzarea, SI, Singh, SK, Dua, K & Gupta, G 2024, 'Circular RNAs in the KRAS pathway: Emerging players in cancer progression', Pathology - Research and Practice, vol. 256, pp. 155259-155259.
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Ishaq, I, Skinner, IW, Mehta, P & Verhagen, AP 2024, 'Description of massage interventions in randomised clinical trials for neck pain; a review using the TIDieR checklist', Clinical Rehabilitation, vol. 38, no. 3, pp. 375-392.
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Objective How interventions are reported can impact the ability to implement these intervention in clinical practice. Therefore, our aim is to assess the reporting of massage interventions in randomised controlled trials for patients with neck pain. Data sources This manuscript concerns a secondary analysis of trials evaluating massage for neck pain selected for a scoping review. An updated literature search was completed using four databases to 31 July 2023. Review methods Trials were selected that evaluate massage interventions. Two independent assessors extracted descriptive information, methodological quality (PEDro-scale) and assessed completeness of reporting of the intervention using the Template for Intervention Description and Replication (TIDier-checklist). We present frequencies of the extracted data. Results We included 35 trials (2840 patients) with neck pain. Most trials (n = 23) included patients with chronic non-specific neck pain. We found a wide variety of massage interventions from Chinese massage, Swedish massage to myofascial release. In addition, the dose, number of sessions and the duration of the intervention varied widely. The methodological quality overall was fair to good (varied between 4–8/10), and we found a moderate completeness of reporting. All trials provided the name of the intervention, 30 (86%) provided a rationale and 26 (74%) trials described details of the massage intervention. Conclusion The massage interventions were moderately described in trials in patients with neck pain, but provided enough information to guide the decision making for designing future Network Meta-analysis as to what trials need to be considered when g...
Ishaq, I, Skinner, IW, Mehta, P, Walton, DM, Bier, J & Verhagen, AP 2024, 'Clinical validation of grouping conservative treatments in neck pain for use in a network meta-analysis: a Delphi consensus study', European Spine Journal, vol. 33, no. 1, pp. 166-175.
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BACKGROUND: A network meta-analysis aims to help clinicians make clinical decisions on the most effective treatment for a certain condition. Neck pain is multifactorial, with various classification systems and treatment options. Classifying patients and grouping interventions in clinically relevant treatment nodes for a NMA is essential, but this process is poorly defined. OBJECTIVE: Our aim is to obtain consensus among experts on neck pain classifications and the grouping of interventions into nodes for a future network meta-analysis. DESIGN: A Delphi consensus study involving neck pain experts worldwide. METHODS: We invited authors of neck pain clinical practice guidelines published from 2014 onwards. The Delphi baseline questionnaire was developed based on the findings of a scoping review, including four items on classifications and 19 nodes. Participants were asked to record their level of agreement on a seven-point Likert scale or using Yes/No/Not sure answer options for the various statements. We used descriptive analysis to summarise the responses on each statement with content analysis of the free-text comments. RESULTS: In total, 18/80 experts (22.5%) agreed to participate in one or more Delphi rounds. We needed three rounds to reach consensus for two classification of neck pain: one based on aetiology and one on duration. In addition, we also reached consensus on the grouping of interventions, including a definition of each node, with the number of nodes reduced to 17. CONCLUSION: With this consensus we clinically validated two neck pain classifications and grouped conservative treatments into 17 well-defined and clinically relevant nodes.
Iwao, HS, Andrews, S & Veldre, A 2024, 'Sensitivity to morphological spelling regularities in Chinese-English bilinguals and English monolinguals', Reading and Writing.
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AbstractEvidence of sensitivity to graphotactic and morphological patterns in English spelling has been extensively examined in monolinguals. Comparatively few studies have examined bilinguals’ sensitivity to spelling regularities. The present study compared late Chinese-English bilinguals and English monolinguals on their sensitivity to systematic inflectional and derivational spelling regularities. One hundred and twenty-nine undergraduate students completed a forced-choice spelling task, in which nonword pairs were presented in a sentence context requiring a choice of the relevant grammatical form. English ability measures were administered to examine possible inter-individual differences in morphological sensitivity. The results showed that both monolingual and bilingual participants demonstrated knowledge of spelling patterns, but the groups differed in their sensitivity to inflectional and derivational spelling regularities. Specifically, bilinguals showed more consistent use of morphological spelling regularities in guiding their decision on spelling choice compared to monolinguals. The results are argued to be consistent with the predictions of statistical learning accounts of spelling acquisition.
Jacob, MF, Fandim, JV, Reis, FJJ, Hartvigsen, J, Ferreira, PH & Saragiotto, BT 2024, 'TELEHEALTH CURRICULUM AT HEALTH CARE HIGHER EDUCATION: AN INTERNATIONAL EDELPHI STUDY', Brazilian Journal of Physical Therapy, vol. 28, pp. 100901-100901.
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Jenkins, LC, Summers, SJ, Nasser, A & Verhagen, A 2024, 'Dry needling perceptions and experiences: A survey of Australian physiotherapists', Musculoskeletal Science and Practice, vol. 69, pp. 102895-102895.
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Jessamine, V, Mehndiratta, S, De Rubis, G, Paudel, KR, Shetty, S, Suares, D, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K 2024, 'The application of nanoparticles as advanced drug delivery systems in Attenuating COPD', Heliyon, vol. 10, no. 3, pp. e25393-e25393.
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Johnson, G, Onslow, M, Carey, B, Jones, M & Kefalianos, E 2024, 'Lidcombe Program telehealth treatment for children 6–12 years of age: A Phase II trial', Journal of Fluency Disorders, vol. 80, pp. 106057-106057.
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Jukic, I, Prnjak, K, Helms, ER & McGuigan, MR 2024, 'Modeling the repetitions‐in‐reserve‐velocity relationship: a valid method for resistance training monitoring and prescription, and fatigue management', Physiological Reports, vol. 12, no. 5, p. e15955.
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AbstractEstablishing a relationship between repetitions left in reserve and the mean absolute velocity (RIR‐velocity relationship) during resistance training (RT) could allow for objective monitoring, prescription, and real‐time adjustment of the training load and set‐volume. Therefore, we examined the goodness of fit and prediction accuracy of general and individual RIR‐velocity relationships in the free‐weight back squat exercise. The effects of sex, training status and history, as well as personality traits, on the goodness of fit and the accuracy of these relationships were also investigated. Forty‐six resistance‐trained people (15 females and 31 males) performed a one‐repetition maximum (1RM) test, and two repetitions to failure (RTF) tests 72 h apart. We found greater goodness of fit of individual RIR‐velocity relationships compared to general RIR‐velocity relationships. Individual, but not general RIR‐velocity relationships established in the first testing session yielded acceptable prediction accuracy of RIR (mean error <2 repetitions) in the subsequent testing session, regardless of the load used. Similar results were obtained when both general and individual RIR‐velocity relationships were averaged across the loads, suggesting that a single RIR‐velocity relationship covering a range of loads can be used instead of traditional RT methods, potentially allowing for better fatigue management and more efficient adaptation.
Kakoty, V, Sarathlal, KC, Kaur, P, Wadhwa, P, Vishwas, S, Khan, FR, Alhazmi, AYM, Almasoudi, HH, Gupta, G, Chellappan, DK, Paudel, KR, Kumar, D, Dua, K & Singh, SK 2024, 'Unraveling the role of glial cell line–derived neurotrophic factor in the treatment of Parkinson’s disease', Neurological Sciences, vol. 45, no. 4, pp. 1409-1418.
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Kemmis-Riggs, J, Dickes, A, Berle, D & McAloon, J 2024, 'Improving parent-child relationships for young parents in the shadow of complex trauma: A Single‑Case Experimental Design Series', Child Psychiatry and Human Development, vol. 55, pp. 94-106.
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This study provides a preliminary evaluation of a dyadic intervention for young parents with a history of complex trauma, Holding Hands Young Parents (HHYP). Four mothers (17–22 years) and toddlers (12–33 months) completed the intervention, designed to improve parent–child relationships, parental self-regulation, self-efficacy and mental health, and child behaviour/emotional problems. An A–B single case experimental design series with follow-up and randomised baseline, used observational and self-report measures throughout. Linear mixed models demonstrated improvement in reciprocity and parental sensitivity over the treatment phase, with no evidence of shifts in scores at beginning or end of treatment. There was no evidence for changes in child engagement, negative states, intrusiveness or withdrawal. Reliable Change Index indicated improvement in parent-reported self-regulation, self-efficacy, stress and child emotional/behavioural problems from baseline to follow-up for all four mothers; depression showed reliable change for three. This study demonstrates relational change between young parents and their toddlers and provides preliminary data on the HHYP protocol.
Kemmis-Riggs, J, Dickes, A, Rogers, K, Berle, D & McAloon, J 2024, 'Improving Parent–Child Relationships for Young Parents in the Shadow of Complex Trauma: A Single-Case Experimental Design Series', Child Psychiatry & Human Development, vol. 55, no. 1, pp. 94-106.
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AbstractThis study provides a preliminary evaluation of a dyadic intervention for young parents with a history of complex trauma, Holding Hands Young Parents (HHYP). Four mothers (17–22 years) and toddlers (12–33 months) completed the intervention, designed to improve parent–child relationships, parental self-regulation, self-efficacy and mental health, and child behaviour/emotional problems. An A–B single case experimental design series with follow-up and randomised baseline, used observational and self-report measures throughout. Linear mixed models demonstrated improvement in reciprocity and parental sensitivity over the treatment phase, with no evidence of shifts in scores at beginning or end of treatment. There was no evidence for changes in child engagement, negative states, intrusiveness or withdrawal. Reliable Change Index indicated improvement in parent-reported self-regulation, self-efficacy, stress and child emotional/behavioural problems from baseline to follow-up for all four mothers; depression showed reliable change for three. This study demonstrates relational change between young parents and their toddlers and provides preliminary data on the HHYP protocol.
Kokkinis, S, Singh, M, Paudel, KR, De Rubis, G, Bani Saeid, A, Jessamine, V, Datsyuk, J, Singh, SK, Vishwas, S, Adams, J, Hansbro, PM, Oliver, B, Gupta, G, Dureja, H & Dua, K 2024, 'Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges', Food Bioscience, vol. 58, pp. 103761-103761.
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Lee, JY, Bhandare, RR, Boddu, SHS, Shaik, AB, Saktivel, LP, Gupta, G, Negi, P, Barakat, M, Singh, SK, Dua, K & Chellappan, DK 2024, 'Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer', Biomedicine & Pharmacotherapy, vol. 173, pp. 116275-116275.
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Luce, C, Palazzo, L, Anderson, ML, Carter-Bawa, L, Gao, H, Green, BB, Ralston, JD, Rogers, K, Su, Y-R, Tuzzio, L, Triplette, M & Wernli, KJ 2024, 'A pragmatic randomized clinical trial of multilevel interventions to improve adherence to lung cancer screening (The Larch Study): Study protocol', Contemporary Clinical Trials, vol. 140, pp. 107495-107495.
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Maguire, PN, Clark, GI, Cosh, SM & Wootton, BM 2024, 'Exploring experiences, barriers and treatment preferences for self-reported perinatal anxiety in Australian women: a qualitative study', Australian Psychologist, vol. 59, no. 1, pp. 46-59.
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Manandhar, B, Pandzic, E, Deshpande, N, Chen, S-Y, Wasinger, VC, Kockx, M, Glaros, EN, Ong, KL, Thomas, SR, Wilkins, MR, Whan, RM, Cochran, BJ & Rye, K-A 2024, 'ApoA-I Protects Pancreatic β-Cells From Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 44, no. 2.
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BACKGROUND: High cholesterol levels in pancreatic β-cells cause oxidative stress and decrease insulin secretion. β-cells can internalize apo (apolipoprotein) A-I, which increases insulin secretion. This study asks whether internalization of apoA-I improves β-cell insulin secretion by reducing oxidative stress. METHODS: Ins-1E cells were cholesterol-loaded by incubation with cholesterol-methyl-β-cyclodextrin. Insulin secretion in the presence of 2.8 or 25 mmol/L glucose was quantified by radioimmunoassay. Internalization of fluorescently labeled apoA-I by β-cells was monitored by flow cytometry. The effects of apoA-I internalization on β-cell gene expression were evaluated by RNA sequencing. ApoA-I-binding partners on the β-cell surface were identified by mass spectrometry. Mitochondrial oxidative stress was quantified in β-cells and isolated islets with MitoSOX and confocal microscopy. RESULTS: An F 1 -ATPase β-subunit on the β-cell surface was identified as the main apoA-I-binding partner. β-cell internalization of apoA-I was time-, concentration-, temperature-, cholesterol-, and F 1 -ATPase β-subunit-dependent. β-cells with internalized apoA-I (apoA-I + cells) had higher cholesterol and cell surface F 1 -ATPase β-subunit levels than β-cells without internalized apoA-I (apoA-I − cells). The internalized apoA-I colocalized with mitochondria and was associated with reduced oxidative stress and increased insulin secreti...
Manandhar, B, Paudel, KR, Clarence, DD, De Rubis, G, Madheswaran, T, Panneerselvam, J, Zacconi, FC, Williams, KA, Pont, LG, Warkiani, ME, MacLoughlin, R, Oliver, BG, Gupta, G, Singh, SK, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 1, pp. 343-356.
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AbstractLung cancer is the second most prevalent type of cancer and is responsible for the highest number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Zerumbone (ZER) is natural compound commonly found in the roots of Zingiber zerumbet which has recently demonstrated anti-cancer activity in both in vitro and in vivo studies. Despite their medical benefits, ZER has low aqueous solubility, poor GI absorption and oral bioavailability that hinders its effectiveness. Liquid crystalline nanoparticles (LCNs) are novel drug delivery carrier that have tuneable characteristics to enhance and ease the delivery of bioactive compounds. This study aimed to formulate ZER-loaded LCNs and investigate their effectiveness against NSCLC in vitro using A549 lung cancer cells. ZER-LCNs, prepared in the study, inhibited the proliferation and migration of A549 cells. These inhibitory effects were superior to the effects of ZER alone at a concentration 10 times lower than that of free ZER, demonstrating a potent anti-cancer activity of ZER-LCNs. The underlying mechanisms of the anti-cancer effects by ZER-LCNs were associated with the transcriptional regulation of tumor suppressor genes P53 and PTEN, and metastasis-associated gene KRT18. The protein array data showed downregulation of several proliferation associated proteins such as AXL, HER1, PGRN, and BIRC5 and metastasis-associated proteins such as DKK1, CAPG, CTSS, CTSB, CTSD, and PLAU. This study provides evidence of potential for increasing the potency and effectiveness of ZER with LCN formulation and developing ZER-LCNs as a treatment strategy for mitigation and treatment of NSCLC.
Onslow, M 2024, 'Ann Packman: Reflections on a career', Journal of Fluency Disorders, vol. 79, pp. 106034-106034.
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Onslow, M, Lowe, R, Jelčić Jakšić, S, Bernstein Ratner, N, Chmela, K, Lim, V & Sheedy, S 2024, 'The Fifth Croatia Stuttering Symposium: Part I. Treatments for early stuttering', Journal of Fluency Disorders, vol. 79, pp. 106022-106022.
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Osman, M, Khalil, J, El-Bahri, M, Swalah Mcdahrou, J, Fahda, R, Mustafa, R, Ooi, A, Attayee, M, Catanzariti, R, Pont, L, Williams, K, Yeung, S, Dua, K, De Rubis, G & Loebenberg, R 2024, 'Decoding epilepsy treatment: A comparative evaluation contrasting cannabidiol pharmacokinetics in adult and paediatric populations', Chemico-Biological Interactions, vol. 394, pp. 110988-110988.
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Paramjot, Wadhwa, S, Sharma, A, Singh, SK, Vishwas, S, Kumar, R, Singh, S, Dua, K, Chellappan, DK & Gupta, G 2024, 'A Comprehensive Review on the Role of Polymers in Ocular DrugDelivery', Current Drug Delivery, vol. 21, no. 1, pp. 16-37.
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Abstract:Amongst different routes of drug delivery systems, ophthalmic drug delivery still requires acareful investigation and strict parameter measurements because the eyes are one of the most sensitiveparts of the body and require special attention. The conventional systems for eyes lead to rapid eliminationof formulation and hence very small contact time on the ocular epithelium. The current review articlecovers various types of polymers used in ocular drug delivery along with their applications/limitations. Polymers are widely used by researchers in prodrug techniques and as a penetrationenhancer in ocular delivery. This article covers the role and use of different polymeric systems whichmakes the final formulation a promising candidate for ophthalmic drug delivery.:The researchers are still facing multiple challenges in order to maintain the therapeutic concentration ofthe drug in the eyes because of its complex structure. There are several barriers that further restrict theintraocular entry of the drug. In order to remove/reduce such challenges, these days various types ofpolymers are used for ocular delivery in order to develop different drug carrier systems for better efficacyand stability. The polymers used are highly helpful in increasing residence time by increasing theviscosity at the ocular epithelium layer. Such preparations also get easily permeated in ocular cells. Thecombination of different polymeric properties makes the final formulation stable with prolonged retention,high viscosity, high permeability, and better bioavailability, making the final formulation a promisingcandidate for ocular drug delivery.
Paudel, KR, Clarence, DD, Panth, N, Manandhar, B, De Rubis, G, Devkota, HP, Gupta, G, Zacconi, FC, Williams, KA, Pont, LG, Singh, SK, Warkiani, ME, Adams, J, MacLoughlin, R, Oliver, BG, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 4, pp. 2465-2483.
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AbstractThe purpose of this study was to evaluate the potential of zerumbone-loaded liquid crystalline nanoparticles (ZER-LCNs) in the protection of broncho-epithelial cells and alveolar macrophages against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro. The effect of the treatment of ZER-LCNs on in vitro cell models of cigarette smoke extract (CSE)-treated mouse RAW264.7 and human BCi-NS1.1 basal epithelial cell lines was evaluated for their anti-inflammatory, antioxidant and anti-senescence activities using colorimetric and fluorescence-based assays, fluorescence imaging, RT-qPCR and proteome profiler kit. The ZER-LCNs successfully reduced the expression of pro-inflammatory markers including Il-6, Il-1β and Tnf-α, as well as the production of nitric oxide in RAW 264.7 cells. Additionally, ZER-LCNs successfully inhibited oxidative stress through reduction of reactive oxygen species (ROS) levels and regulation of genes, namely GPX2 and GCLC in BCi-NS1.1 cells. Anti-senescence activity of ZER-LCNs was also observed in BCi-NS1.1 cells, with significant reductions in the expression of SIRT1, CDKN1A and CDKN2A. This study demonstrates strong in vitro anti-inflammatory, antioxidative and anti-senescence activities of ZER-LCNs paving the path for this formulation to be translated into a promising therapeutic agent for chronic respiratory inflammatory conditions including COPD and asthma.
Paudel, KR, Mohamad, MSB, De Rubis, G, Reyes, R-J, Panth, N, Dureja, H, Gupta, G, Singh, SK, Madheswaran, T, Collet, T, Hansbro, PM, Dua, K & Chellappan, DK 2024, '18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration', Journal of Drug Delivery Science and Technology, vol. 95, pp. 105523-105523.
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Plakogiannis, FA, Weidmann, J, Fraser, B, Kwong, J, Asi, D, Kumar, P, Baldock, M, Naamo, J, Baluja, R, Catanzariti, R, Yeung, S, Pont, L, Williams, K, De Rubis, G, Dua, K & Bukhari, NI 2024, 'Investigation of smoking on the antiplatelet response to clopidogrel: Unravelling the Smoker’s Paradox.', Pathology - Research and Practice, pp. 155290-155290.
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Power, E, Attard, MC, Lanyon, LE & Togher, L 2024, 'Efficacy of online communication partner training package for student healthcare professionals', International Journal of Language & Communication Disorders, vol. 59, no. 1, pp. 304-326.
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AbstractBackgroundPeople with aphasia are vulnerable recipients of healthcare. The nature of the communicative environment and the communication disability can adversely impact access to timely and quality healthcare. Student healthcare professionals are often underprepared to interact successfully with people with aphasia and may benefit from communication partner training (CPT).AimsTo investigate the potential effectiveness and acceptability of a brief, two‐part introductory Supported Conversation for Adults with Aphasia (SCA™)‐based CPT package, delivered to a sample of students across a diverse range of healthcare disciplines.Methods & ProceduresA pre–post‐within group experimental design was used to investigate the potential effectiveness and acceptability of an online CPT package (50 minute module + 1 hour workshop) for healthcare students. The Aphasia Attitudes, Strategies and Knowledge (AASK) survey measured participants’ knowledge of aphasia, facilitative communication strategies and attitudes towards people with aphasia. Data were collected pre‐training, following the training module and following the workshop, and 6 weeks post‐training. Statistical analysis was conducted on the AASK data. In addition, participant feedback (ratings and open text responses) was collected after the workshop. Ratings were analysed descriptively, and thematic content analysis was used for open text responses.Outcomes & Results236 participants completed the pre‐training AASK and 106 completed the AASK at subsequent time points. Statistically significant gains were demonstrated from pre‐ to post‐module completion. Between the end of the module and the end of the workshop, some gains were maintained and oth...
Prajapat, VM, Aalhate, M, Sriram, A, Mahajan, S, Maji, I, Gupta, U, Kumari, D, Singh, K, Kalia, NP, Dua, K, Singh, SK & Singh, PK 2024, 'Amphotericin B loaded nanoemulsion: Optimization, characterization and in-vitro activity against L. donovani promastigotes', Parasitology International, vol. 100, pp. 102848-102848.
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Prasher, P, Sharma, M, Agarwal, V, Singh, SK, Gupta, G, Dureja, H & Dua, K 2024, 'Cationic cycloamylose based nucleic acid nanocarriers', Chemico-Biological Interactions, vol. 395, pp. 111000-111000.
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Quartermaine, JR, Rose, TA, Auld, ML & Johnston, LM 2024, 'Factors impacting positive and negative participation of young people with cerebral palsy: a Delphi study of consumers and health professionals', Disability and Rehabilitation, vol. 46, no. 7, pp. 1330-1338.
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Ralston, JD, Anderson, M, Ng, J, Bashir, A, Ehrlich, K, Burns-Hunt, D, Cotton, M, Hansell, L, Hsu, C, Hunt, H, Karter, AJ, Levy, SM, Ludman, E, Madziwa, L, Omura, EM, Rogers, K, Sevey, B, Shaw, JAM, Shortreed, SM, Singh, U, Speight, J, Sweeny, A, Tschernisch, K, Sergei Tschernisch, S & Yarborough, L 2024, 'Preventing severe hypoglycemia in adults with type 2 diabetes (PHT2): Design, delivery and evaluation framework for a randomized controlled trial', Contemporary Clinical Trials, vol. 139, pp. 107456-107456.
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Rios, WRC, Almeida Silva, HJ, Pontes, NS, Pontes-Silva, A, Avila, MA, Saragiotto, BT, Júnior, JJDA, Barbosa, GM & de Souza, MC 2024, 'Use of cupping therapy in musculoskeletal disorders: A cross-sectional study on the profile, training, and practice of Brazilian physical therapists', Musculoskeletal Science and Practice, vol. 71, pp. 102943-102943.
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Ryan, CG, Karran, EL, Wallwork, SB, Pate, JW, O’Keeffe, M, Fullen, BM, Livadas, N, Jones, N, Toumbourou, JW, Gilchrist, P, Cameron, PA, Fatoye, F, Ravindran, D & Lorimer Moseley, G 2024, 'We Are All in This Together—Whole of Community Pain Science Education Campaigns to Promote Better Management of Persistent Pain', The Journal of Pain, vol. 25, no. 4, pp. 902-917.
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Persistent pain is a major public health issue-estimated to affect a quarter of the world's population. Public understanding of persistent pain is based on outdated biomedical models, laden with misconceptions that are contrary to best evidence. This understanding is a barrier to effective pain management. Thus, there have been calls for public health-based interventions to address these misconceptions. Previous pain-focussed public education campaigns have targeted pain beliefs and behaviours that are thought to promote recovery, such as staying active. However, prevailing pain-related misconceptions render many of these approaches counter-intuitive, at best. Pain Science Education improves understanding of 'how pain works' and has been demonstrated to improve pain and disability outcomes. Extending Pain Science Education beyond the clinic to the wider community seems warranted. Learning from previous back pain-focussed and other public health educational campaigns could optimise the potential benefit of such a Pain Science Education campaign. Pain Science Education-grounded campaigns have been delivered in Australia and the UK and show promise, but robust evaluations are needed before any firm conclusions on their population impact can be made. Several challenges exist going forward. Not least is the need to ensure all stakeholders are involved in the development and implementation of Pain Science Education public messaging campaigns. Furthermore, it is crucial that campaigns are undertaken through a health equity lens, incorporating underrepresented communities to ensure that any intervention does not widen existing health inequalities associated with persistent pain. PERSPECTIVE: Public misconceptions about pain are a significant public health challenge and a viable intervention target to reduce the personal, social, and economic burden of persistent pain. Adaptation of Pain Science Education, which improves misconceptions in a clinical setting, int...
Santos, VS, Fandim, JV, Silva, FG, Hatakeyama, BA, Fioratti, I, Costa, LOP, Saragiotto, BT & Yamato, TP 2024, 'Evaluation of methodological and reporting quality of systematic reviews on conservative non-pharmacological musculoskeletal pain management in children and adolescents: A methodological analysis', Musculoskeletal Science and Practice, vol. 69, pp. 102902-102902.
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Seah, R & Berle, D 2024, 'Correction to: Negative Attributions as a Source of Vulnerability for Trauma-Related Shame and PTSD Symptoms', Journal of Rational-Emotive & Cognitive-Behavior Therapy, vol. 42, no. 1, pp. 133-134.
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Seah, R & Berle, D 2024, 'Negative Attributions as a Source of Vulnerability for trauma-related Shame and PTSD Symptoms', Journal of Rational-Emotive & Cognitive-Behavior Therapy, vol. 42, no. 1, pp. 1-16.
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AbstractShame is a common trauma response that is associated with the development and maintenance of PTSD. Phenomenological descriptions of shame indicate that shame arises from internal, stable and global causal attributions (negative attributions) for the precipitating event. The current study investigated whether negative attributions would be associated with higher levels of shame and PTSD, and whether shame would mediate the relationship between causal attributions and PTSD. As negative attributions may reflect a common transdiagnostic process in both depression and PTSD, it also examined whether depression would moderate this relationship. Eighty-seven participants meeting criteria for a Criterion A stressor were administered a structured PTSD diagnostic interview and a series of self-report measures. Findings indicate that shame mediated the relationship between internal, stable and global trauma-related causal attributions and PTSD symptoms. Further, depression did not moderate this relationship, indicating that negative causal attributions are associated with shame and PTSD independent of depression. Results provide empirical support for the cognitive concomitants of trauma-related shame, which raise the possibility that addressing negative attributions through cognitive therapeutic methods may be pertinent in reducing trauma-related shame. Future prospective data is needed to establish cognitive antecedents to shame.
Shaikh, MAJ, Altamimi, ASA, Afzal, M, Gupta, G, Singla, N, Gilhotra, R, almalki, WH, Kazmi, I, Alzarea, SI, Prasher, P, Singh, SK & Dua, K 2024, 'Unraveling the impact of miR-21 on apoptosis regulation in glioblastoma', Pathology - Research and Practice, vol. 254, pp. 155121-155121.
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Sharma, DS, Wadhwa, S, Gulati, M, Kumar, B, Chitranshi, N, Gupta, VK, Alrouji, M, Alhajlah, S, AlOmeir, O, Vishwas, S, Khursheed, R, Saini, S, Kumar, A, Parveen, SR, Gupta, G, Zacconi, F, Chellappan, DK, Morris, A, Loebenberg, R, Dua, K & Singh, SK 2024, 'Corrigendum to - Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug, Vol. 224, 1 January 2023, Pages 810-830', International Journal of Biological Macromolecules, vol. 265, pp. 131069-131069.
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Sher, A, Wootton, BM & Paparo, J 2024, 'A preliminary investigation of the mediating roles of self‐compassion and emotion dysregulation in the relationship between maladaptive perfectionism and obsessive‐compulsive behaviors', Journal of Clinical Psychology, vol. 80, no. 3, pp. 591-609.
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AbstractIntroductionRecent research has highlighted an association between maladaptive perfectionism and obsessive‐compulsive disorder (OCD). However, the mechanisms underlying this relationship are not well understood. The primary aim of this preliminary study was to investigate whether self‐compassion and emotion dysregulation independently mediated this relationship. The secondary aim was to determine whether serial mediation existed between these factors. Whether these relations held for overall obsessive‐compulsive (OC) symptoms, versus distinct dimensions of OCD, was also of interest.MethodThree hundred and ninety‐two university students (Mage = 21.81, SD = 8.01), predominantly female (79.18%), participated in an online questionnaire that included a dimensional measure of OCD. Scales assessing maladaptive perfectionism, self‐compassion, emotion dysregulation, and negative emotion states were also included.ResultsGreater maladaptive perfectionism was related to more severe OCD. Emotion dysregulation, but not self‐compassion, independently mediated this relationship. A serial mediation relationship was found, in that greater maladaptive perfectionism was associated with lower self‐compassion, which was linked to greater emotion dysregulation, and in turn related to more severe OC behaviors. In addition, distinct patterns emerged for separate OC dimensions.ConclusionsThese findings highlight emotion regulation and self‐compassion as potential targets for OCD prevention, especially in individuals with symptoms in the symmetry and unacceptable thoughts dimensions.
Sims, MA, Menzies, RE & Menzies, RG 2024, 'A systematic review of the relationship between death anxiety, capability for suicide, and suicidality', Death Studies, vol. 48, no. 1, pp. 16-26.
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This systematic review aimed to examine the relationship between death anxiety and suicidality in adults, and the impact of death anxiety interventions on the capability for suicide and suicidality. MEDLINE, PsycINFO, PubMed, and Web of Science were extensively searched using purpose-related keywords from the earliest to July 29th, 2022. A total of 376 participants were included across four studies which met inclusion. Death anxiety was found to relate significantly and positively with rescue potential, and although weak, negatively with suicide intent, circumstances of attempt, and a wish to die. There was no relationship between death anxiety and lethality or risk of lethality. Further, no studies examined the effects of death anxiety interventions on the capability for suicide and suicidality. It is imperative that future research implements a more rigorous methodology to establish the relationship between death anxiety and suicidality and establish the impacts of death anxiety interventions on the capability for suicide and suicidality.
Singh, S, Saxena, S, Sharma, H, Paudel, KR, Chakraborty, A, MacLoughlin, R, Oliver, BG, Gupta, G, Negi, P, Singh, SK & Dua, K 2024, 'Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer', Pathology - Research and Practice, vol. 256, pp. 155222-155222.
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Smith, R, Bryant, L & Hemsley, B 2024, 'Perspectives of people with dysphagia and their supporters on the potential for 3D food printing to improve mealtime-related quality of life', Disability and Rehabilitation: Assistive Technology, vol. 19, no. 3, pp. 1032-1040.
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PURPOSE: To understand the views of people with dysphagia and their supporters on the feasibility of using 3D food printing to improve the visual appeal of texture-modified foods and their mealtime experiences. MATERIALS AND METHODS: Nine people with dysphagia and four of their supporters engaged in a virtual 3D food printing experience and interview over Zoom© about their impressions and usability of the printer and potential for it to improve their mealtime experiences. The in-depth interviews were analysed using thematic analysis and usability heuristics. RESULTS: Four content themes in the interviews impacted on the feasibility of 3D food printing. They related to the practicality, design acceptability, population suitability, and cost of 3D food printing. Usability heuristic analysis revealed that print quality, user control, error prevention, and handling of food consistencies would impact on use. Perceived low efficiency and increased time required to create food shapes meant participants were cautious in their overall impressions of the role of the device. CONCLUSION: After an immersive virtual experience with a 3D food printer, people with dysphagia and their supporters identified a wide range of usability issues that would need to be addressed prior to implementation and in the future design of user-friendly 3D food printers for people with dysphagia. Future research should include people with dysphagia and their supporters in 3D food printer design and implementation trials.Implications for Rehabilitation3D food printing may provide people with dysphagia who require texture-modified food a way to produce visually appealing texture-modified food if usability issues are addressed.3D food printing could improve participation in meal preparation if the person with dysphagia chooses the food and the shape and size of the printed food shape.
Solanki, N, Gupta, G, Chellappan, DK, Singh, SK, Gulati, M, Paudel, KR, Hansbro, PM, Dua, K, Bhan, S, Saini, M & Dureja, H 2024, 'Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases', Endocrine, Metabolic & Immune Disorders - Drug Targets, vol. 24, no. 1, pp. 116-129.
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Background:In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases.Objective:Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species.Methods:Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases.Results:These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects.Conclusion:Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflamma-tion. The review further explores the therapeutic potential of boswellic acids in
Stendell, L, Stubbs, DPW, Rivera, E, Rogers, APK, Verhagen, PAP, Davis, PGM, Middleton, PJW & De Oliveira, DCQ 2024, 'Are Middle/Older-Aged Adults With A Spinal Cord Injury Engaging In Leisure-Time Physical Activity? A Systematic Review And Meta-Analysis', Archives of Rehabilitation Research and Clinical Translation, pp. 100335-100335.
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Thapa, R, Afzal, M, Goyal, A, Gupta, G, Bhat, AA, Almalki, WH, Kazmi, I, Alzarea, SI, Shahwan, M, Kukreti, N, Ali, H, Dureja, H, Kumar, P, Singh, TG, Kuppusamy, G, Singh, SK & Dua, K 2024, 'Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics', Life Sciences, vol. 345, pp. 122613-122613.
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Thapa, R, Afzal, O, Afzal, M, Gupta, G, Bhat, AA, Hassan almalki, W, Kazmi, I, Alzarea, SI, Saleem, S, Arora, P, Singh, SK & Dua, K 2024, 'From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression', Pathology - Research and Practice, vol. 253, pp. 154959-154959.
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Turbitt, E, Kohler, JN, Brothers, KB, Outram, SM, Rini, C, Sahin-Hodoglugil, N, Leo, MC & Biesecker, BB 2024, 'The Parent PrU: A measure to assess personal utility of pediatric genomic results', Genetics in Medicine, vol. 26, no. 1, pp. 100994-100994.
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Urionagüena, A, Piquer-Martinez, C, Benrimoj, SI, Calvo, B, Garcia-Cardenas, V, Gastelurrutia, MA, Martinez-Martinez, F & Fernandez-Llimos, F 2024, 'Mapping the concept of health care integration: A lexicographic analysis of scientific literature', Research in Social and Administrative Pharmacy, vol. 20, no. 5, pp. 506-511.
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Watson, P, Prior, K, Ridley, N, Monds, L, Manning, V, Wiers, RW & Le Pelley, ME 2024, 'Sign-tracking to non-drug reward is related to severity of alcohol-use problems in a sample of individuals seeking treatment', Addictive Behaviors, vol. 154, pp. 108010-108010.
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Watson, P, Thrailkill, EA, Corbit, LH & Bouton, ME 2024, 'Introduction to the special issue: Goal direction and habit in operant behavior', Journal of the Experimental Analysis of Behavior, vol. 121, no. 1, pp. 3-7.
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White, S, Turbitt, E, Rogers, K, Tucker, K, McEwen, A, Best, M, Phillips, JL & Jacobs, C 2024, 'A survey of genetic and palliative care health professionals’ views of integrating genetics into palliative care', European Journal of Human Genetics, vol. 32, no. 1, pp. 109-116.
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AbstractGenetic counselling and testing have utility for people with palliative care needs and their families. However, genetic and palliative care health professionals have described difficulties initiating palliative-genetic discussions. Between March and July 2022, we received n = 73 surveys (6% response rate) from genetic and palliative care health professionals in Australia and New Zealand that assessed and compared barriers and facilitators. The main perceived barrier to both groups was palliative care health professionals’ lack of genetic knowledge (44%). Most palliative care health professionals were ‘not at all confident’ performing several activities, including discussing DNA banking (52%) and knowing their legal responsibilities when sharing genetic information (58%). The most frequently selected facilitator for genetic health professionals was fostering close relationships with palliative care health professionals (52%), while palliative care health professionals indicated a genetic referral template (51%) would be of assistance. Almost all participants agreed genetic discussions do not undermine the central ethos of palliative care (87%). Fewer palliative care health professionals considered themselves well situated to have genetic discussions with a palliative patient’s family compared to genetic health professionals (p = 0.014). Our results suggest that genetic and palliative care health professionals support integrating genetics into palliative care, although refinement of the palliative care health professionals’ role in this process is required. We have identified intervention targets to overcome barriers related to knowledge and confidence, which ought to be integrated into future interventions designed to support health professionals deliver the benefits of genetic information to people with palliative care needs and their families.
Wootton, BM, McDonald, S, Melkonian, M, Karin, E, Titov, N & Dear, BF 2024, 'Efficacy and acceptability of a self-guided internet-delivered cognitive-behavioral educational program for obsessive-compulsive symptoms with international recruitment', Cognitive Behaviour Therapy, vol. 53, no. 2, pp. 133-151.
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Yeong, RHT, Hodge, CB & Gunasekaran, P 2024, 'Assessing the impact of COVID-19 on Australian public interest in critical care', Anaesthesia and Intensive Care, vol. 52, no. 1, pp. 75-76.
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Yin, M, Wadhwa, R, Marshall, JE, Gillis, CM, Kim, RY, Dua, K, Palsson-McDermott, EM, Fallon, PG, Hansbro, PM & O’Neill, LAJ 2024, '4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development', The Journal of Immunology, vol. 212, no. 1, pp. 13-23.
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Abstract 4-Octyl itaconate (4-OI) is a derivative of the Krebs cycle–derived metabolite itaconate and displays an array of antimicrobial and anti-inflammatory properties through modifying cysteine residues within protein targets. We have found that 4-OI significantly reduces the production of eosinophil-targeted chemokines in a variety of cell types, including M1 and M2 macrophages, Th2 cells, and A549 respiratory epithelial cells. Notably, the suppression of these chemokines in M1 macrophages was found to be NRF2-dependent. In addition, 4-OI can interfere with IL-5 signaling and directly affect eosinophil differentiation. In a model of eosinophilic airway inflammation in BALB/c mice, 4-OI alleviated airway resistance and reduced eosinophil recruitment to the lungs. Our findings suggest that itaconate derivatives could be promising therapeutic agents for the treatment of eosinophilic asthma.
Zaga, CJ, Papasavva, CS, Hepworth, G, Freeman-Sanderson, A, Happ, MB, Hoit, JD, McGrath, BA, Pandian, V, Rose, L, Sutt, A-L, Tuinman, PR, Wallace, S, Bellomo, R, Vogel, AP & Berney, S 2024, 'Development, feasibility testing, and preliminary evaluation of the Communication with an Artificial airway Tool (CAT): Results of the Crit-CAT pilot study', Australian Critical Care, vol. 37, no. 1, pp. 127-137.
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